纸喷雾软电离质谱分析性能研究

纸喷雾电离源 质谱法具有操作简单、价格低廉、无需繁琐的预处理便可对复杂样品进行快速分析等特点。作为一种电喷雾离子源，关于纸喷雾电离源与常用电喷雾电离源、纳升电喷雾电离源之间离子化性能的差异鲜有报道。本文采用汽油、肌红蛋白、细胞色素c和GAP样品作为分析对象，系统地比较了上述3种电离源的离子化特征，发现电离程度呈现纸喷雾电离源<电喷雾电离源<纳升电喷雾电离源的趋势，其中纸喷雾电离源表现出最软的电离特性。该研究对于深入了解不同电离源性能之间的差异，拓展纸喷雾电离源的应用范围具有参考价值。

Exploration of the Soft Ionization Performance of Paper Spray Mass Spectrometry

Paper spray mass spectrometry has received considerable attentions in recent years due to its simple operation, low cost and without tedious sample pretreatment prior to analysis. However, paper spray ionization (PSI) as a type of electrospray-based ionization source, there are few reports on exploring the ionization performance differences between it and two frequently used electrospray ionization (ESI) and nanoelectrospray ionization (nanoESI). Herein the ionization performance of above three ionization sources was compared systematically by using gasolines, myoglobin, cytochrome c and glycidyl azide polymer (GAP) as samples. According to the obtained results, the ionization performance demonstrated the following trend: PSI