活血解毒丸联合阿莫西林分散片对急性乳腺炎的疗效及对淋巴细胞、炎症因子水平的影响

目的 分析活血解毒丸联合阿莫西林分散片对急性乳腺炎患者淋巴细胞、炎症因子水平及疗效影响。方法 回顾性选取2014年1月—2017年2月河南中医药大学第一附属医院收治的急性乳腺炎患者298例，根据治疗方法不同分为对照组和观察组。对照组患者采用阿莫西林分散片治疗，观察组患者采用活血解毒丸联合阿莫西林分散片治疗。观察两组患者治疗后主要症状积分情况、症状消失时间、复发情况及淋巴细胞、炎症因子水平变化情况。结果 两组患者治疗后乳房胀痛、局部皮肤灼热、乳房结块及恶寒发热等主要症状积分均较治疗前改善，同组治疗前后比较差异有统计学意义（P<0.05）；观察组患者治疗后主要症状积分均优于对照组，差异有统计学意义（P<0.05）。观察组患者退热时间、红肿消退时间、肿痛消失时间及通乳时间均较对照组短，差异有统计学意义（P<0.05）。两组患者治疗后淋巴细胞、CRP及IL-6水平均较治疗前下降，同组治疗前后比较差异有统计学意义（P<0.05）；观察组患者治疗后淋巴细胞、CRP及IL-6水平均低于对照组，差异有统计学意义（P<0.05）。观察组患者1年内乳房肿块、乳房疼痛及乳房溢液的总复发率低于对照组，差异有统计学意义（P<0.05）。结论 活血解毒丸联合阿莫西林分散片治疗急性乳腺炎可快速改善患者症状，降低患者淋巴细胞、CRP、IL-6水平并减少复发。

Effect of Huoxue Jiedu Pill on lymphocyte and inflammatory factors in patients with acute mastitis

Objective To analyze the influence of Huoxue Jiedu Pill on lymphocyte, inflammatory factor level and curative effect in patients with acute mastitis. Methods Review from January 2014 to February 2017 in our hospital 298 cases of acute mastitis patients, according to the different treatment methods were divided into control group and observation group. The control group was treated with Amoxicillin Dispersible Tablets treatment, the observation group were treated by Huoxue Jiedu pill combined with Amoxicillin Dispersible Tablets treatment. To observe the main symptoms of the two groups of patients after treatment points, symptoms disappeared time, recurrence and the changes of lymphocytes and inflammatory cytokines. Results Two groups of patients after treatment of breast pain, skin burning, the main symptoms of breast lump and fever and other points were improved compared with before treatment, observation group patients after symptom scores were better than the control group (P<0.05). The patients in the observation group were pyretolysis time, swelling time, swelling and pain disappeared time and Tongru time was shorter than the control group (P<0.05). Two groups of patients after treatment of lymphocytes, CRP and IL-6 levels were lower than that before treatment, patients in the observation group after treatment, CRP lymphocytes, and IL-6 were lower than the control group (P<0.05). The patients in the observation group were within 1 years of breast lumps, breast pain And the total recurrence rate of breast discharge was higher than that of the control group (P<0.05). Conclusion Treatment of acute mastitis with Huoxue Jiedu pills can quickly improve the symptoms of patients, reduce the levels of lymphocytes, CRP, IL-6, and reduce the recurrence rate.