多西他赛联合顺铂、氟尿嘧啶腹腔灌注治疗胃癌晚期患者的临床疗效

目的 考察多西他赛联合顺铂、氟尿嘧啶腹腔灌注治疗胃癌晚期患者的临床效果。方法 选取2011年1月—2015年12月于安徽医科大学附属第四医院诊治的晚期胃癌患者100例，采用随机数字法分为试验组（48例）和对照组（52例），对照组患者给予多西他赛联合顺铂、氟尿嘧啶静脉治疗，试验组患者给予多西他赛联合顺铂、氟尿嘧啶腹腔灌注，比较两组患者的临床治疗有效率、不良反应发生率及2年复发率和病死率。结果 试验组患者的临床治疗有效率为77.08%，对照组患者的临床治疗有效率46.15%，差异具有统计学意义（P<0.05）。试验组患者的不良反应发生率为14.58%，对照组患者的不良反应发生率为34.62%，差异具有统计学意义（P<0.05）；与对照组相比，试验组患者的复发率显著降低，差异具有统计学意义（P<0.05）。结论 多西他赛联合顺铂、氟尿嘧啶腹腔灌注治疗胃癌晚期患者的临床效果较好，可显著降低患者的复发率，安全性也较好。

Clinical efficacy of docetaxel combined with cis-platinum, fluorouracil with abdominal cavity perfusion in the treatment of advenced gastric carcinoma

Objective To investigate the clinical efficacy of docetaxel combined with cis-platinum, fluorouracil with abdominal cavity perfusion in the treatment of advenced gastric carcinoma.Methods From January 2011 to December 2015 were collected 100 cases advenced gastric carcinoma patients in the fourth affiliated hospital of Anhui medical university, according to randm numbers divided into experimental group (48 cases) and control group (52 cases), the control group was given docetaxel and cis-platinum, fluorouracil through intravenous, the experimental group was given docetaxel combined with cis-platinum, fluorouracilabdominal cavity perfusion, compared with the effect rate of clinical treatment, incidence of adverse reaction and recurrence rate and death rate after two years.Results The effect rate of clinical treatment of experimental group is 77.08%, the effect rate of clinical treatment of control group is 46.15%, the difference was statistically significant (P<0.05). The incidence of adverse reaction of experimental group is 14.58%, the incidence of adverse reaction of control group is 34.62%, the difference was statistically significant (P<0.05). Compared with the control group, the recurrence rate of the experimental group significantly decreased, the difference was statistically significant (P<0.05).Conclusion Docetaxel combined with cis-platinum, fluorouracil with abdominal cavity perfusion in the treatment of advenced gastric carcinoma has good effect, can significantly decreased the recurrence rate, the safety is high.