| 枸札总黄酮类化合物抗脂质过氧化研究 |
| |
| 引用本文： | 黄元庆,鲁建华.枸札总黄酮类化合物抗脂质过氧化研究[J].卫生研究,1999,28(2):115-116. |
| |
| 作者姓名： | 黄元庆 鲁建华 |
| |
| 摘 要： | 利用Ｆｅ＾２＋－Ｃｙｓ－Ｈｉｓ体系诱发鼠肝线粒体和红细胞产生脂质过氧化的方法，研究了枸札总黄类化合物（ＴＦＬ）的抗脂质过氧化作用。结果表明，ＴＦＬ可阻断该体系发的鼠肝线粒体脂质过氧化，当ＴＦＬ终浓度在０．０２５－２．０ｍｇ／ｍｌ范围时，对丙二醛（ＭＤＡ）生成阻断率为３８．３８％－９９．９６％，呈剂量－效应关系，同时具有保持线粒体膜流动性的作用、扫描电镜观察到ＴＦＬ对脂质过氧化所致红细胞形态结构的皮
|
| 关 键 词： | 枸札总黄酮 线粒体 脂质过氧化 实验研究 |
The protective effects of total flavonoids from Lycium Barbarum L. on lipid peroxidation of liver mitochondria and red blood cell in rats] |
| |
| Y Huang,J Lu,Y Shen,J Lu.The protective effects of total flavonoids from Lycium Barbarum L. on lipid peroxidation of liver mitochondria and red blood cell in rats][J].Journal of Hygiene Research,1999,28(2):115-116. |
| |
| Authors: | Y Huang J Lu Y Shen J Lu |
| |
| Affiliation: | Department of Nutrition and Food Hygiene, Faculty of Preventive Medicine, Ningxia Medical College, Yinchuan 750004, China. |
| |
| Abstract: | The protective effects of total flavonoids from Lycium Barbarum L. (TFL) on lipid peroxidation in mitochondria and red blood cells (RBC) induced by oxygen radicals produced by Fe2+ cysteine system were investigated. The mitochondria lipid peroxidation (measured as malondialdehyde, MDA) was significantly inhibited by TFL with a dose-response relation between the concentrations of 0.025 and 2.0 mg/ml, and the fluidity of mitochondria membrane was also protected effectively. It was observed by scan electron microscope, that the shape of RBC in the Fe2+ system was damaged significantly. The shape of RBC was remained with the addition of TFL. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
|
