西酞普兰治疗早泄的临床观察

目的:探讨西酞普兰治疗早泄的临床疗效和安全性。方法:将2011年5月至2012年5月男科门诊就诊的80例早泄患者随机分为治疗组和对照组,每组40例。治疗组每天口服西酞普兰20 mg,对照组口服安慰剂,记录治疗前、治疗2周和4周后患者阴道内射精潜伏时间(IELT)和性交满意度分值。结果:治疗组治疗2、4周后IELT分别为(5.64±1.31)min和(7.12±1.56)min,均比治疗前(0.91±0.18)min]明显延长(P均<0.01),且西酞普兰治疗4周后的IELT明显高于2周后(P<0.01);治疗组治疗2、4周后性交满意度分别为(6.1±1.3)分和(6.3±1.1)分,与治疗前(2.5±0.8)分]相比有明显提高(P<0.01),而治疗2周和4周后性交满意度无显著性差异(P>0.05)。对照组治疗2、4周后IELT和性交满意度分别为(1.02±0.24)min、1.01±0.21 min和(3.0±1.1)分、(3.1±1.3)分,与治疗前(0.95±0.17)min和(3.2±1.2)分]比较,均无显著性差异(P均>0.05)。结论:每天口服西酞普兰20 mg,对早泄患者IELT和性交满意度均有明显改善,西酞普兰治疗早泄具有较好的临床疗效和安全性。

Efficacy of citalopram on premature ejaculation: A clinical observation

Objective: To investigate the clinical efficacy and reliability of citalopram in the treatment of premature ejaculation.Methods: We included in this study 80 patients who came to our andrological clinic for premature ejaculation from May 2011 to May 2012,and randomly assigned them to a treatment and a control group of equal number to receive citalopram(20 mg/d) and placebo,respectively.We recorded the intravaginal ejaculation latency time(IELT) and sexual intercourse satisfaction scores before and at 2 and 4 weeks after treatment,and compared them between the two groups.Results: In the treatment group,IELT was significantly longer at 2 and 4 weeks than before treatment(5.64±1.31] and 7.12±1.56] min vs 0.91±0.18] min,P<0.01),so was it at 4 than at 2 weeks(P<0.01),and the sexual intercourse satisfaction scores were remarkably higher at 2 and 4 weeks than before treatment(6.1±1.3 and 6.3±1.1 vs 2.5±0.8,P<0.01),but with no significant difference between 2 and 4 weeks(P>0.05).The control group showed no significant differences in the mean IELT and sexal intercourse satisfaction scores between pre-and post-treatment(1.01±0.21] vs 0.95±0.17] min;3.1±1.3 vs 3.0±1.1,P >0.05).Conclusion: Oral medication of citalopram at 20 mg/d can significantly prolong IELT and improve sexual intercourse satisfaction in patients with premature ejaculation.