2007～2008年我院药品不良反应报告分析

目的：分析我院药品不良反应（ADR）发生的特点与一般规律,促进临床合理用药。方法：对我院2007～2008年11个月上报的456份ADR报告,按患者年龄、性别、药物过敏史、给药途径、引起ADR的药品种类、涉及器官或系统以及临床表现等进行统计、分析。结果：静脉滴注较其它给药途径更易发生ADR（326例,占71.49%）。抗感染药引发ADR的比例最高（262例,占57.46%）,头孢菌素类是引发ADR的主要抗感染药物（125例,占47.71%）,头孢替唑居首,其次为中药制剂。ADR的临床表现以皮疹、瘙痒等皮肤及其附件损害为主,其次为消化系统。结论：应加强ADR监测意识,完善相关报告分析制度。

Analysis of ADR Cases in Our Hospital from 2007 to 2008

OBJECTIVE： To analyze the characteristics and general patterns of adverse drug reactions （ADR） occurred in our hospital in order to promote rational clinical drug use. METHODS： 456 ADR case reports collected in our hospital from 2007 to 2008 were analyzed statistically in respect of patients＇ age and sex, allergic history, route of administration,drug category, organs and systems involved and clinical manifestation etc. RESULTS： Of the total 456 cases, 326 （37.23 % ） were induced via intravenous drip, 262 （57.46%） were induced by anti - infective drugs, of which, Cephalothins accounted for 47.71 % （125 cases）, leading the first place was Ceftezole followed by Chinese materia medica preparations. The main presentations of the ADRs were skin rash, pruritus and lesions of skin and its appendages followed by the lesion of digestive system. CONCLUSION： Awareness on ADR monitoring should be strengthened and the related ADR reporting system should be improved.