PTEN蛋白表达与乳腺癌患者临床病理学特征相关性的 Meta分析

目的：评价PTEN蛋白表达与乳腺癌患者临床病理学特征的关联性。方法通过PubMed、Embase、Cochrane Li‐brary、中国知网（CNKI）及万方数据库检索所有已发表的关于乳腺癌患者组织中PTEN蛋白表达与临床病理学参数的相关性研究。应用RevMan 5．2软件进行分析，计算表达比值比（OR）和95％可信区间（CI），并对研究文献进行异质性检验和偏倚评估。结果共28篇研究文献（3172例患者）纳入Meta分析。PTEN在乳腺癌组织中的表达与患者的雌激素受体（OR＝3．16，95％CI：2．01～4．97，P＜0．01）、孕激素受体（OR＝2．27，95％ CI：1．70～3．04，P＜0．01）、淋巴转移（OR＝0．36，95％ CI：0．27～0．49， P＜0．01）、临床分期（OR＝2．59，95％ CI：2．04～3．30，P＜0．01）和组织学分级（OR＝2．19，95％ CI：1．74～2．75，P＜0．01）均有显著相关性。结论 PTEN异常表达可能在乳腺癌的发生、进展、浸润及预后中起重要作用，是乳腺癌早期诊断和内分泌治疗中较有价值的分子标志物。

Clinicopathological significance of PTEN protein expression in breast cancer:a Meta-analysis

Objective To evaluate the association between the expression of PTEN protein and the clinicopathological char‐acteristics of breast cancer patients .Methods All eligible studies regarding the association of PTEN protein expression with clini‐copathological features in patients with breast cancer were retrieved from PubMed ,Embase ,Cochrane Library ,CNKI and Wanfang databases .Odds ratio(OR) with corresponding 95% confidence interval(95% CI) form eligible studies were pooled .Heterogeneity and publication bias were also evaluated .All analyses were operated using RevMan 5 .2 software .Results A total of 28 articles con‐taining 3 172 patients were ultimately included for this Meta‐analysis .Our findings revealed that the expression level of PTEN was significantly correlated with estrogen receptor status(OR= 3 .16 ,95% CI:2 .01 -4 .97 ,P< 0 .01) ,progesterone receptor status (OR=2 .27 ,95% CI:1 .70 -3 .04 ,P<0 .01) ,lymph node metastasis(OR=0 .36 ,95% CI :0 .27 -0 .49 ,P<0 .01) ,clinical stage (OR=2 .59 ,95% CI:2 .04-3 .30 ,P<0 .01) and histological grade(OR=2 .19 ,95% CI:1 .74-2 .75 ,P<0 .01) .Conclusion Aber‐rant PTEN expression might have strong impacts on carcinogenesis ,tumor progression ,invasion and prognosis ,which makes it a potential biomarker for early cancer screening and endocrine therapy in breast cancer .