类氨基酸基载药水凝胶敷料的制备与性能

为制备一种具有良好生物相容性、可控缓释的物理交联的水凝胶敷料，选用类氨基酸单体N-丙烯酰基甘氨酰胺（NAGA）与生物发酵产物衣康酸（IA）为单体，在紫外光条件下，通过自由基聚合，在不需要外加任何交联剂条件下即可形成水凝胶聚（N-丙烯酰基甘氨酰胺-衣康酸）（P(NAGA-IA)）。所得水凝胶具有溶胶-凝胶转变温度（UCST）、较高的水溶胀率（40倍）及力学性能（压缩模量最高540 kPa）、较优的药物负载性和缓释性，这是因为NAGA单元提供分子间多重氢键作用，进而赋予了水凝胶较优的综合性能；而IA单元赋予了聚合物的pH刺激响应性，从而可诱导药物的释放。因此，所得P (NAGA-IA)水凝胶可作敷料用于创伤治疗。

Preparation and properties of amino acid based drug loaded hydrogel

Hydrogel is generally used as medical dressing because of its high water content and 3D network. However, it is a big challenge to achieve controllable drug release from the hydrogels. In order to prepare a kind of hydrogel dressing with good biocompatibility and controllable drug release, physical crosslinking was carried out. In this study, amino acid monomer N-acryl glycine amide (NAGA) and biological fermentation product itaconic acid (IA) were used as monomers. Under UV light, the hydrogel Poly(N-acryloylglycine-itaconic acid) (P(NAGA-IA)) could be formed without addition of crosslinking agent by self-polymerization. The obtained hydrogel showed lower sol-gel transition temperature (UCST), higher water swelling (40 times) and mechanical properties (540 kPa of maximum compression modulus), and better drug loading and release. NAGA chains provided intermolecular hydrogen bonds to give better comprehensive properties of hydrogels. Moreover, IA units provided pH stimuli responsive property, which could induce drug release. Therefore, the P (NAGA-IA) hydrogel could be used as wound dressing for wound healing.