| 铟-二乙三胺五乙酸配合物的合成与表征 |
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| 引用本文： | 马睿,刘春玲. 铟-二乙三胺五乙酸配合物的合成与表征[J]. 沈阳理工大学学报, 2012, 34(4): 72-74,80 |
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| 作者姓名： | 马睿 刘春玲 |
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| 作者单位： | 沈阳理工大学 环境与化学工程学院,辽宁沈阳,110159 |
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| 摘 要： | 以二乙三胺五乙酸(dtpa)为配体合成含有自由羧酸基的稀散金属离子InⅢ配合物,分子式为K[ InⅢ(Hdtpa)]·3.5 H2O.[InⅢ(Hdtpa)]-配离子中InⅢ与来自同一个二乙三胺五乙酸的三个氮原子和四个氧原子构成七配位面冠三方柱体结构.其中[ InⅢ(Hdtpa)]-配离子提供一个可用于修饰的未参与配位的自由羧酸基(-CH2COOH),配合物通过修饰与具有定向功能的生物大分子相接可形成定向放射性抗肿瘤药物.
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| 关 键 词： | 铟 配合物 二乙三胺五乙酸 合成 表征 |
Synthesis and Characterization of In Complex with Diethylenetriaminepentaacetic Acid |
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| MA Rui , LIU Chunling. Synthesis and Characterization of In Complex with Diethylenetriaminepentaacetic Acid[J]. Transactions of Shenyang Ligong University, 2012, 34(4): 72-74,80 |
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| Authors: | MA Rui LIU Chunling |
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| Affiliation: | (Shenyang Ligong University,Shenyang 110159,China) |
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| Abstract: | The In complex with dtpa as the ligand was synthesized and its composition and structure were characterized as K[InⅢ(Hdtpa)]·3.5H2O.InⅢ ion is coordinated by three nitrogen atoms and four carboxyl oxygen atoms from one dtpa ligand,forming a coordination polyhedron of seven-coordinate pseudo-monocapped trigonal prism.The complex anion [ In Ⅲ(Hdtpa)]-can provide a free carboxyl group(-CH2COOH)which can be used for further embellishment.The results provide convincing scientific basis for further investigation and development of tumor-targeting diagnostic and therapeutic drugs. |
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| Keywords: | In complex dtpa synthesis characterization |
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