| 临床微生物快速检测新技术发展现状与前景 |
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| 引用本文： | 宁雅婷,杨启文,陈新飞,郁谨菡,李雪,徐英春.临床微生物快速检测新技术发展现状与前景[J].协和医学杂志,2021,12(4):427-432. |
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| 作者姓名： | 宁雅婷 杨启文 陈新飞 郁谨菡 李雪 徐英春 |
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| 作者单位： | 1.中国医学科学院 北京协和医学院 北京协和医院检验科 疑难重症及罕见病国家重点实验室，北京 100730 |
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| 基金项目： | 北京市临床重点专科医学检验科卓越项目ZK201000北京协和医学院学科建设项目201920200101 |
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| 摘 要： | 感染性疾病起病急、进展快，早期精准识别和监测病原体耐药性对患者预后及遏制耐药至关重要。临床微生物常规技术已无法满足快速诊疗的需求，因此快速检测技术成为检验与临床关注的焦点。本文论述快速鉴定与药物敏感性检测的最新技术研究现状、问题及未来发展要点，旨在为临床微生物实验室未来新技术的引入提供参考。
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| 关 键 词： | 临床微生物学 快速检测 鉴定 基质辅助激光解吸电离飞行时间质谱 光谱技术 电化学生物传感器 宏基因组测序 体外抗菌药物敏感性试验 |
| 收稿时间： | 2021-05-12 |
Current Situation and Prospect of New Techniques for Rapid Clinical Microbiological Testing |
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| Affiliation: | 1.Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China2.Graduate School, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China3.Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China |
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| Abstract: | Infectious diseases begin and progress rapidly, so early accurate identification and detection of pathogen resistance is crucial for the prognosis of patients and the curb on drug resistance. Conventional clinical microbiological technology has been unable to meet the needs of rapid diagnosis and treatment. Therefore, rapid detection technology becomes the focus of clinic and clinical laboratory. This paper reviews the research status of the latest technology for rapid identification and detection of drug sensitivity, and discusses their problems and the key points of future development, providing reference to the introduction of new technologies in the clinical microbiological laboratory in the future. |
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