| 基于多指标综合评价胡黄连提取工艺研究 |
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| 引用本文： | 侯文彬,周福军,单淇,刘昌孝.基于多指标综合评价胡黄连提取工艺研究[J].天津中医药大学学报,2013,32(3):154-156. |
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| 作者姓名： | 侯文彬 周福军 单淇 刘昌孝 |
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| 作者单位： | 300193 天津中医药大学;300193 天津药物研究院 天津市中药质量控制技术工程实验室, 中药现代制剂与质量控制技术国家地方联合工程实验室;300193 天津药物研究院 天津市中药质量控制技术工程实验室, 中药现代制剂与质量控制技术国家地方联合工程实验室;300193 天津药物研究院 天津市中药质量控制技术工程实验室, 中药现代制剂与质量控制技术国家地方联合工程实验室;300193 天津药物研究院 释药技术与药代动力学国家重点实验室 |
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| 基金项目： | 国家科技支撑计划基金项目(2007BAI41B06). |
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| 摘 要： | 目的]] 通过正交设计筛选胡黄连的提取工艺,优化出最佳工艺参数。方法]以提取液中胡黄连苷Ⅰ、Ⅱ转移率及出膏率的加和进行综合评价,采用L9(34)正交实验优选最佳提取工艺。结果]胡黄连最佳提取工艺为原药材最粗粉浸泡24 h,以每分钟1.5 mL的流速渗漉,收集16倍量的渗漉液。结论]优选的胡黄连提取工艺合理可行,为实际生产提供参考。
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| 关 键 词： | 胡黄连 正交实验 胡黄连苷Ⅰ 胡黄连苷Ⅱ 渗漉提取 |
| 收稿时间： | 2013/4/27 0:00:00 |
Evaluation of extracted art of Rhizoma Picrorhizae based on multiple criteria comprehensively |
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| HOU Wen-bin,ZHOU Fu-jun,SHAN Qi and LIU Chang-xiao.Evaluation of extracted art of Rhizoma Picrorhizae based on multiple criteria comprehensively[J].Journal of Tianjin University of Traditonal Chinese Medicine,2013,32(3):154-156. |
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| Authors: | HOU Wen-bin ZHOU Fu-jun SHAN Qi and LIU Chang-xiao |
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| Affiliation: | Tianjin University of TCM, Tianjin 300193, China;Tianjin Institute of Pharmaceutical Research, Tianjin Engineering Laboratory of Quality Control Technology of TCM, National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China;Tianjin Institute of Pharmaceutical Research, Tianjin Engineering Laboratory of Quality Control Technology of TCM, National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China;Tianjin Institute of Pharmaceutical Research, Tianjin Engineering Laboratory of Quality Control Technology of TCM, National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine (Tianjin), Tianjin 300193, China;Tianjin Institute of Pharmaceutical Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin 300193, China |
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| Abstract: | Objective] To optimize the extraction process of Rhizoma Picrorhizae by an orthogonal experiment and to determine the best extraction parameters. Methods] The L9(34) orthogonal test was employed based on a multiple criteria comprehensively evaluating the yields of picroside I, picroside II, and total extracts. Results] The optimum extraction process was characterized as: soaking the crude rhizome powders for 24 h and percolating them with 1.5 mL/min of the flow rate and 16 folds of extraction volume were collected. Conclusion] The extraction technique is stable and available.This study provides an experimental basis for the industrial production of Rhizoma Picrorhizae. |
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| Keywords: | Rhizoma Picrorhizae orthogonal test picroside I picroside II percolation |
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