泥鳅多糖对小鼠耐缺氧作用的研究

目的　研究泥鳅多糖 (MAP)对小鼠耐缺氧作用的影响。方法　连续灌胃小鼠不同剂量的泥鳅多糖 14d ,末次给药后 1h ,进行密闭缺氧实验、亚硝酸钠中毒缺氧实验和急性脑缺血性缺氧实验。以存活时间、Hb、MDA含量及SOD活性为指标 ,观察MAP对小鼠耐缺氧作用的影响。结果　实验结果表明 ,MAP可延长小鼠在不同缺氧条件下的存活时间 ,以 5 0mg·kg-1·d-1剂量效果最佳。MAP可增高小鼠血红蛋白含量 ,抑制组织脂质过氧化反应以及增加血浆中SOD活性。结论　MAP具有提高实验小鼠耐缺氧能力的作用

Effects of misgurnus anguillicaudatus polysaccharides on antihypoxia capacity in mice

AIM The effects of misgurnus anguillicaudatus Polysaccharides(MAP) on the antihypoxia capacity in mice were studied. METHODS The mice were administered with various doses of MAP for 14 days and then were exposed to hypoxia. The survival time in mice, the content of hemoglobin (Hb), the content of MDA and the activity of superoxide dismutase (SOD) were examined. RESULTS MAP significantly prolonged the survival time in mice exposed to hypoxia. The optimal dose was 50 mg·kg -1 ·d -1 . MAP could inhibit lipid peroxidation in tissues, and increase Hb content and the activity of SOD in plasma. CONCLUSION MAP are the biological active components in Misgurnus anguillicaudatus against hypoxia.