头部低温对高血压性脑出血脑疝患者血清NO、SOD、Glut的影响

目的探讨高血压性脑出血脑疝(HIHE)患者在头部低温条件下一氧化氮(NO)、谷氨酸(Glut)和超氧化物歧化酶(SOD)的变化。方法采用硝酸酶还原法、羟胺氧化法、HPLC法测定31例HIHE患者加用头部低温治疗与30例不加用者入院第2天、第10天血中NO、SOD、Glut的含量水平。另设30名健康人为对照组。并对前两组生存者生活质量进行比较。结果两组HIHE患者入院第2天NO、Glut明显升高和SOD降低(P<0.01);治疗7天后NO、Glut、SOD比较,头部低温组较入院第2天NO、Glut明显降低和SOD升高(P<0.05,P<0.01),不加用低温组无显著变化(P>0.05),头部低温组与不加用低温组比较有显著性差异(P<0.05)。头部低温组较不加用低温组生存者出院时NDS、ADL明显降低(P<0.05)。结论HIHE早期患者NO、Glut明显升高,SOD显著降低。头部低温可有效降低HIHE患者血清中NO、Glut含量,提高其生存者的生活质量。

Effects of head hypothermia on levels of NO,SOD,Glut in serum of patients with hypertensive intracerebral hemorrhage encephalocele

Objective To investigate changes of levels of nitric oxide (NO), superoxide dismutase (SOD), glutamate (Glut) and the effects of head hypothermia on the levels of NO, SOD, Glut in serum of patients with hypertensive intracerebral hemorrhage encephalocele (HIHE). Methods The 61 cases with HIHE were divided into head hypothermia group (HHG, 31 cases) and observation group (OG, 30 cases); 30 healthy subjects were selected as control group (HCG). All cases of HHG were treated by head hypothermia. The NO, SOD, Glut in serum in 61 cases with HIHE in the HHG, OG at 2th, 10th day after hospitalized and 30 cases in the HCG were measured by nitrate reductase method, hydroxylaimine oxidation method and highperformance liquid chromatography(HPLC), respectively. The life quality on survivel were assessed separately in the 61 cases with HIHE. Results The HHG, OG had a higher NO, Glut and lower SOD than the HCG at 2th day after hospitalized (P<0.01). There were significant differences in the NO, Glut, SOD in the HHG at 7th day after treatment than at 2nd day after hospotalized (P<0.05,P<0.01). There were significant differences in the NO, Glut, SOD in the HHG than the OG at 8th day after treatment (P<0.05). The Neurological deficiency score (NDS) and activities of daily life (ADL)were significantly lower in the HHG than that in the OG after treatment (P<0.05).Conclusion The head hypothermia can reduce the levels of the NO, Glut in serum and improve the life quality on survival in patients with the HIHE.