来曲唑、他莫昔芬和氯米芬治疗多囊卵巢综合征不孕疗效比较

目的比较多囊卵巢综合征(PCOS)不孕患者经纠正内分泌代谢紊乱后应用3种不同促排卵药物的效果及对子宫内膜的影响。方法选择2009年3月至2010年1月中山大学孙逸仙纪念医院妇产科生殖中心128例PCOS不孕患者,于本院行第1次促排卵,有高雄激素或胰岛素抵抗者经预处理至少3个月。随机分为3组,来曲唑44个周期、他莫昔芬40个周期和氯米芬44个周期。结果月经第10天的子宫内膜厚度,他莫昔芬组(6.4±1.2)mm]高于来曲唑组(5.4±1.7)mm]和氯米芬组(5.4±1.3)mm](P=0.01);HCG日血雌二醇(E2)水平,来曲唑组(838.6±678.2)pmol/L]低于他莫昔芬组(2629.2±1931.5)pmol/L]和氯米芬组(1971.2±1222.8)pmol/L](P<0.001);3组间加用尿促性腺激素(HMG)周期数,HCG日子宫内膜厚度、血黄体生成素及孕酮、直径≥18mm成熟卵泡数,妊娠率和早期流产率,差异无统计学意义(P>0.05);HCG日子宫内膜的厚度与注射HCG的月经周期日及月经第10天的子宫内膜厚度呈正相关(P<0.05),与药物的种类及HCG日血E2水平等无显...

Letrozole,tamoxifen or clomiphene citrate for ovulation induction in women with polycystic ovarian syndrome after pretreatment:a prospective randomized trial

Objective To compare the effects of letrozole,tamoxifen and clomiphene citrate for ovulation induction in women with PCOS.Methods The study comprised a total of 128 infertile women with PCOS.Patients were randomized to treatment with letrozole 5mg/d (44 cycles),tamoxifen 20mg/d (40 cycles) or clomiphene citrate 50mg/d (44 cycles) for 5 days starting on day 5 of menses or withdraw bleeding.The following indexes were compared:number of mature follicles,serum sex hormones,endometrial thickness and pregnancy an...