| 人体关键药代动力学参数预测方法 |
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| 引用本文： | 祝建平,孙建国,彭英,王广基.人体关键药代动力学参数预测方法[J].中国临床药理学与治疗学,2011,16(6):699-709. |
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| 作者姓名： | 祝建平 孙建国 彭英 王广基 |
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| 作者单位： | 中国药科大学药物代谢动力学重点实验室,南京210009,江苏 |
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| 基金项目： | 中央高校基本科研业务费专项资助(JKP2009007); 国家自然科学基金(30901832); “十一五”重大新药创制项目资助(2009ZX09304-001) |
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| 摘 要： | 分布容积、清除率、半衰期和生物利用度是重要的药物代谢动力学参数,决定着药物在体内的暴露程度与暴露时间,在新药开发过程中尽早预测人体内这些参数对选择与优化潜在新药有重要价值。本文综述了采用临床前药代动力学实验数据、体外吸收与代谢数据、化合物理化性质、计算机模拟等多种方法预测人体内关键药代动力学参数的研究及其进展。
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| 关 键 词： | 预测 药代动力学参数 体外-体内相关性 |
Prediction of key pharmacokinetic parameters in human |
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| ZHU Jian-ping,SUN Jian-guo,PENG Ying,WANG Guang-ji.Prediction of key pharmacokinetic parameters in human[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(6):699-709. |
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| Authors: | ZHU Jian-ping SUN Jian-guo PENG Ying WANG Guang-ji |
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| Affiliation: | ZHU Jian-ping,SUN Jian-guo,PENG Ying,WANG Guang-jiKey Laboratory of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 210009,Jiangsu,China |
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| Abstract: | Volume of distribution,clearance,half of life and bioavailability are crucial pharmacokinetic parameters determining the extent and sustained time of drugs exposed in vivo.Thus,in the stage of drug discovery and development,it is of particular interest to estimate the pharmacokinetic parameters of drug candidates in human as early as possible to select the most promising compounds for further development.This paper reviews recent developments in prediction of human key pharmacokinetic parameters based upon ... |
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| Keywords: | Prediction Pharmacokinetic parameters In vitro-in vivo correlation |
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