| 苦碟子总黄酮对脑缺血性损伤保护作用的实验研究 |
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| 引用本文： | 贾德武,罗胜勇,叶寿山,贾德云,李心伟,马征,李睿.苦碟子总黄酮对脑缺血性损伤保护作用的实验研究[J].中国临床药理学与治疗学,2011,16(6):616-620. |
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| 作者姓名： | 贾德武 罗胜勇 叶寿山 贾德云 李心伟 马征 李睿 |
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| 作者单位： | 1. 安徽医科大学附属医院药剂科,合肥230032,安徽
2. 安徽省医学科学研究院,合肥230061,安徽 |
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| 摘 要： | 目的:研究苦碟子总黄酮(TFS)对小鼠急性脑缺血和大鼠局灶性脑缺血的保护作用。方法:结扎小鼠双侧颈总动脉建立脑缺血模型,观察TFS对小鼠死亡率及死亡时间的影响。建立局灶性脑缺血(MCAO)模型,观察TFS对大鼠行为学、脑梗死范围的影响。测定脑含水量及脑组织中一氧化氮合酶(NOS)和诱导型一氧化氮合酶(iNOS)含量。结果:与模型组比较,TFS16、8 mg/kg组可降低缺血小鼠的死亡率,延长死亡时间(P<0.05,P<0.01);16、8、4 mg/kg组可改善行为障碍,降低行为学评分(P<0.05,P<0.01);105、mg/kg组可减少MCAO大鼠脑梗死范围,降低脑组织含水量及NOS和iNOS含量(P<0.05)。结论:TFS对缺血性脑损伤有保护作用,其机制可能与抑制iNOS有关。
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| 关 键 词： | 苦碟子总黄酮 脑缺血 一氧化氮合酶 诱导型一氧化氮合酶 |
Protective effects studing of total flavonoids of sowthistle-leafixeris seedling on cerebral ischemia injury in rats |
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| JIA De-wu,LUO Sheng-yong,YE Shou-shan,JIA De-yun,LI Xin-wei,MA Zheng,LI Rui.Protective effects studing of total flavonoids of sowthistle-leafixeris seedling on cerebral ischemia injury in rats[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(6):616-620. |
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| Authors: | JIA De-wu LUO Sheng-yong YE Shou-shan JIA De-yun LI Xin-wei MA Zheng LI Rui |
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| Affiliation: | JIA De-wu1,LUO Sheng-yong2,YE Shou-shan2,JIA De-yun2,LI Xin-wei2,MA Zheng2,LI Rui21Department of Pharmacy,the First Affiliated Hospital of Anhui Medical University,Hefei 230032,Anhui,China,2Anhui Institute of Medical Sciences,Hefei 230061,Chin |
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| Abstract: | AIM:To investigate the protective effects of total flavonoids of sowthistle-leafixeris seedling(TFS) against acute cerebral ischemia in mice and focal cerebral ischemia in rats. METHODS: The occlusion of bilateral common carotid arteries with vagus in mice was used for make the acute cerebral ischemia models.The survival time and the death rate were observed.The permanent occlusion of the proximal of the right middle cerebral artery(MCA)was used for make the focal cerebral ischemia models.The extent of neur... |
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| Keywords: | TFS Cerebral ischemia NOS iNOS |
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