用γ射线显影法研究磷酸川芎嗪脉冲塞胶囊在犬胃肠道内的崩解释药和转运行为

为了解所研制的新型脉冲给药系统一磷酸川芎嗪脉冲塞胶囊能否在体内实现脉冲释药及其在体内的崩解释药部位。采用7射线显影法研究了在含药片中含有放射性同位素。^99mTc标记二乙三胺五醋酸（DTPA）的脉冲塞胶囊在犬胃肠道内的崩解释药和转运行为。结果表明，自制的脉冲塞胶囊在间隔一定时间（时滞）后，其中的含药片开始在犬的胃幽门部位或小肠崩解释药。且释药较为迅速。与希望的脉冲释药方式一致。此外．脉冲塞胶囊在犬体内的释药时滞随溶蚀塞重量的减少而缩短，可以通过调节凝胶塞的重量来获得所需时滞的脉冲塞胶囊满足时辰治疗的要求。

Investigation of the In Vivo Desintegration and Transit Behavior of Tetramethylpyrazine Phosphate Pulsincap Capsule in the Gastrointestinal Tract of Dogs by Gamma Scintigraphy

This study aims to investigate whether a self-made novel pulsatile drug delivery system--razine phosphate pulsincap capsule-will achieve a pulsatile drug release in vivo and to study the drug release sites. A gamma scintigraphic study was conducted to assess the in vivo transit and release behavior of the pulsincap capsule with a drug tablet containing 99mTc-labeled diethylenetriamine pentaacetic acid (DTPA) in the gastrointestinal (GI) tract of dog. The results revealed that after a time interval (lag time), the drug tablet began to disintegrate and then released at the pylorus of stomach or in the small intestine of dogs with a relatively rapid release rate, which was consistent with the expected pulsed release pattern. The in vivo lag time of the pulsincap capsule in dog was shortened with the decrease of erodible plugs(EP) weight. Thus we can achieve a desirable lag time to meet the chronotherapeutic requirements by adjusting the weight of EP.