颅内原发性Rosai-Dor fman病：附3例报告并文献复习

目的探讨颅内原发性Rosai-D0r fman病（RDD）的MRI表现及病理特点，提高对该病的认识。方法对3例经病理证实的RDD患者MRI及病理特点进行回顾性分析，并对相关文献进行复习。结果3例患者均行头颅MRI平扫加增强检查。2例为多发病灶，1例为单发病灶，均位于脑实质外；T1WI和T2WI均显示呈等信号影，其中2例基于脑膜生长，1例位于脑室内；增强后病灶呈明显均匀强化。显微镜下见较多组织细胞，淋巴细胞及浆细胞浸润伴纤维化，其中巨大组织细胞浆内可见大小不等的淋巴细胞；免疫组化显示这些组织细胞S-100蛋白和CD68标记阳性。结论颅内RosAI-D0r fman病较少见，易误诊，免疫组化检查有助于鉴别诊断。若MR检查发现基于脑膜生长的多发或孤立性病灶，应考虑到R0sai-D0r fman病的可能。

Primary intracranial rosai-dorfman disease： report of 3 cases and literature review

Objective To investigate the magnetic resonance imaging （MRI） manifestations and pathological features of primary intracranial Rosai-Dorfman disease （RDD）, so as to improve the knowledge of this disease. Methods 3 cases of primary intracranial RDD confirmed pathologically were evaluated by analyzing MRI and pathologic features, along with literature review. Results 3 cases perfomed by MRI plain scan and enhanced scan were located outtside the brain paren chyma, of which 2 cases were multiple lesions, 1 case was single lesiongs. T1WI and T2WI scan showed the lesions, of which 2 cases were mening growth based and 1 case was in the ventriciles. After enhancement, the lesions were showed homogeneous enhancement. Histologically, the lesions consisted of variable numbers of pale-stained histocytes with empe ripolesis were positive for S-100 protein and CD68 by immunohistochemical analysis. Conclusion Primary intracranial Ro sai-Dorfman disease is rare, which could be diagnosed by immunhistochemical examination. The possibility of central nerv ous system Rosai-Dorfman disease should be considered when single or multiple dural-based mass lesions.