| 尿毒清颗粒治疗慢性肾衰竭研究概况 |
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| 引用本文： | 孟宪杰,万毅刚,魏晴雪,陈好利,史喜苗,黄燕如,姚建.尿毒清颗粒治疗慢性肾衰竭研究概况[J].中国中药杂志,2013,38(21):3651-3655. |
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| 作者姓名： | 孟宪杰 万毅刚 魏晴雪 陈好利 史喜苗 黄燕如 姚建 |
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| 作者单位： | 南京中医药大学 中西医结合鼓楼临床医学院, 江苏 南京 210029;南京大学 医学院 附属鼓楼医院 中医科, 江苏 南京 210008;南京中医药大学 中西医结合鼓楼临床医学院, 江苏 南京 210029;南京中医药大学 中西医结合鼓楼临床医学院, 江苏 南京 210029;南京中医药大学 中西医结合鼓楼临床医学院, 江苏 南京 210029;南京中医药大学 中西医结合鼓楼临床医学院, 江苏 南京 210029;Department of Molecular Signaling University of Yamanashi, Yamanashi, Japan 409-3898 |
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| 基金项目： | 南京市卫生青年人才培养工程项目;江苏省中医药局科技项目(LZ11116) |
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| 摘 要： | 尿毒清颗粒(uremic clearance granule,UCG)的主要生物活性成分包括异黄酮、大黄素、黄芪甲苷、芍药苷、丹酚酸A等。在临床上,UCG可以改善慢性肾衰竭(chronic renal failure,CRF)患者的肾功能,并减少CRF相关并发症;其药理机制包括抑制转化生长因子(transforming growth factor,TGF)-β1表达,减轻足细胞损伤,抑制肾小管上皮细胞转分化,改善微炎症状态,抑制氧化应激,减轻胰岛素抵抗等。
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| 关 键 词： | 尿毒清颗粒 慢性肾衰竭 药理机制 |
| 收稿时间： | 2013/6/23 0:00:00 |
Overview research of uremic ulearance granule treating chronic renal failure |
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| MENG Xian-jie,WAN Yi-gang,WEI Qing-xue,CHEN Hao-li,SHI Xi-miao,HUANG Yan-ru and YAO Jian.Overview research of uremic ulearance granule treating chronic renal failure[J].China Journal of Chinese Materia Medica,2013,38(21):3651-3655. |
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| Authors: | MENG Xian-jie WAN Yi-gang WEI Qing-xue CHEN Hao-li SHI Xi-miao HUANG Yan-ru and YAO Jian |
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| Affiliation: | Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China;Department of Molecular Signaling University of Yamanashi, Yamanashi 409-3898, Japan |
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| Abstract: | |
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| Keywords: | uremic clearance granul chronic renal failure pharmacological mechanism |
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