| 双白术内酯对豚鼠离体心房肌的作用 |
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| 引用本文： | 蒲含林,王正濂,黄巧娟,许实波,林永成,吴雄宇.双白术内酯对豚鼠离体心房肌的作用[J].中国药理学通报,2000,16(1):60-62. |
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| 作者姓名： | 蒲含林 王正濂 黄巧娟 许实波 林永成 吴雄宇 |
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| 作者单位： | 中山大学药学系药物药理学研究室!广州510275(蒲含林,王正濂,黄巧娟,许实波),中山大学化学系天然有机研究室!广州510275(林永成,吴雄宇) |
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| 摘 要： | 目的 以豚鼠离体心房肌为材料 ,研究新结构化合物双白术内酯对离体心房肌的作用。方法 采用豚鼠离体心房肌 ,测定给药前后心房的心率、心肌收缩力 ,左心房静息后增强作用及正性阶梯现象。结果 双白术内酯 (终浓度为1 19× 10 -5mol·L-1)能明显降低豚鼠离体右心房肌的收缩力 ,同时减慢其心率 ,此作用可完全被阿托品取消 ;双白术内酯使豚鼠离体左心房肌的正性阶梯作用降低 ,对左心房肌的静息后增强作用无影响。结论 双白术内酯对豚鼠离体心房肌有负性肌力和负性频率作用
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| 关 键 词： | 双白术内酯 心房肌 阿托品 维拉帕米 正性阶梯现象 |
Effects of biatractylolide on isolated guinea pig myocardium |
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| PU HanLin,WANG ZhengLian,HUANG QiaoJuan,XU ShiBo,LIN YongCheng,WU XiongYu.Effects of biatractylolide on isolated guinea pig myocardium[J].Chinese Pharmacological Bulletin,2000,16(1):60-62. |
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| Authors: | PU HanLin WANG ZhengLian HUANG QiaoJuan XU ShiBo LIN YongCheng WU XiongYu |
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| Affiliation: | PU HanLin,WANG ZhengLian,HUANG QiaoJuan,XU ShiBo,LIN YongCheng1,WU XiongYu1 |
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| Abstract: | AIM To study the effects of biatractylolide on isolated guinea pig
atrium. METHODS The isolated rat
atria were adopted. Before and after giving biatractylolide,verapamil, the heart rate,
contractile force of atri um, post-rest contraction and staircase were measured. RESULTS
Biatractylolide could prominetly inhibit
contractile force and decrease heart rate of isolated right atrium of guinea pig. These
actions could be blocked by a tropine completely. It could inhibit positive staircase
phenomenon of isolated l eft atrium of guinea atrium. It had no effect to the PREP of the
isolated left a trium. CONCLUSION Biatractylolide
possessed negative inotropic and chronotropic actions on isolated guinea pig. |
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| Keywords: | biatractylolide heart atrium atropine verapamil positive staircase phenomenon |
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