Selective Cardiomyocyte Oxidative Stress Leads to Bystander Senescence of Cardiac Stromal Cells |
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| Authors: | Hlne Martini Lise Lefevre Sylvain Sayir Romain Itier Damien Maggiorani Marianne Dutaur Dimitri J Marsal Jrme Roncalli Nathalie Pizzinat Daniel Cussac Angelo Parini Jeanne Mialet-Perez Victorine Douin-Echinard |
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| Affiliation: | 1.Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1048, University of Toulouse, 31400 Toulouse, France; (H.M.); (L.L.); (D.M.); (M.D.); (D.J.M.); (J.R.); (N.P.); (D.C.); (A.P.);2.Institute Cardiomet, FHU IMPACT, University Hospital of Toulouse, 31400 Toulouse, France; (S.S.); (R.I.) |
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| Abstract: | Accumulation of senescent cells in tissues during normal or accelerated aging has been shown to be detrimental and to favor the outcomes of age-related diseases such as heart failure (HF). We have previously shown that oxidative stress dependent on monoamine oxidase A (MAOA) activity in cardiomyocytes promotes mitochondrial damage, the formation of telomere-associated foci, senescence markers, and triggers systolic cardiac dysfunction in a model of transgenic mice overexpressing MAOA in cardiomyocytes (Tg MAOA). However, the impact of cardiomyocyte oxidative stress on the cardiac microenvironment in vivo is still unclear. Our results showed that systolic cardiac dysfunction in Tg MAOA mice was strongly correlated with oxidative stress induced premature senescence of cardiac stromal cells favoring the recruitment of CCR2+ monocytes and the installation of cardiac inflammation. Understanding the interplay between oxidative stress induced premature senescence and accelerated cardiac dysfunction will help to define new molecular pathways at the crossroad between cardiac dysfunction and accelerated aging, which could contribute to the increased susceptibility of the elderly to HF. |
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| Keywords: | stress-induced premature senescence oxidative stress monoamine oxidase A SASP cardiac mesenchymal stromal cells CCR2+ Macrophages |
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