| 基于信息熵赋值法的正交联用Box-Behnken设计-响应面法优化黄丝郁金醋炙工艺研究 |
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| 引用本文： | 权亮,赵永峰,陈志敏,周海婷,李文兵,胡昌江.基于信息熵赋值法的正交联用Box-Behnken设计-响应面法优化黄丝郁金醋炙工艺研究[J].中草药,2018,49(8):1823-1828. |
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| 作者姓名： | 权亮 赵永峰 陈志敏 周海婷 李文兵 胡昌江 |
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| 作者单位： | 成都中医药大学;成都市中草药研究所;国家中医药管理局"中药配方颗粒质量与疗效评价"重点研究室;四川新绿色药业科技发展有限公司 |
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| 基金项目： | 国家中药标准化项目（ZYBZH-Y-SC-42,ZYY-2017-151） |
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| 摘 要： | 目的基于信息熵赋权法的正交联用Box-Behnken设计-响应面法(BBD-RSM)优化黄丝郁金醋炙工艺,优化其醋制炮制工艺。方法以HPLC法测定醋郁金中姜黄素、去甲氧基姜黄素和双去甲氧基姜黄素的量,作为评价指标,采用正交试验考察米醋用量、闷润时间、炒制温度、炒制时间对黄丝郁金醋炙工艺的影响;在正交试验的基础上,进一步采用BBD-RSM考察闷润时间、炒制温度和炒制时间对该炮制工艺的影响。结果正交试验确定的黄丝郁金最佳醋炙工艺为加入10%米醋,拌匀闷润10 min,炒制温度130℃,炒制10 min;BBD-RSM确定最佳炮制工艺为闷润时间12 min,炒制温度150℃,炒制时间8 min。验证实验结果表明该工艺条件重复性良好,具有合理性和可行性。结论此实验方法可行,模型、数据可靠,优化了黄丝郁金醋炙工艺。
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| 关 键 词： | 黄丝郁金 醋炙工艺 Box-Behnken设计-响应面法 正交设计 信息熵赋权法 姜黄素 去甲氧基姜黄素 双去甲氧基姜黄素 |
| 收稿时间： | 2017/10/31 0:00:00 |
Optimization of processing technology of stir-frying with vinegar of Curcuma Longa Radix by orthogonal design and Box-Behnken design-response surface based on entropy method |
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| QUAN Liang,ZHAO Yong-feng,CHEN Zhi-min,ZHOU Hai-ting,LI Wen-bing and HU Chang-jiang.Optimization of processing technology of stir-frying with vinegar of Curcuma Longa Radix by orthogonal design and Box-Behnken design-response surface based on entropy method[J].Chinese Traditional and Herbal Drugs,2018,49(8):1823-1828. |
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| Authors: | QUAN Liang ZHAO Yong-feng CHEN Zhi-min ZHOU Hai-ting LI Wen-bing and HU Chang-jiang |
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| Affiliation: | Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Chengdu Institute of Chinese Herbal Medicine, Chengdu 610016, China,Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China,Key Laboratory of Chinese Medicine Formulations Particle Mass and Clinical Evaluation, State Administration of Traditional Chinese Medicine, Chengdu 611900, China;Neo-Green Pharmaceutical Co., Ltd., Chengdu 611900, China and Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;Key Laboratory of Chinese Medicine Formulations Particle Mass and Clinical Evaluation, State Administration of Traditional Chinese Medicine, Chengdu 611900, China |
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| Abstract: | |
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| Keywords: | Curcumae Longae Radix processing technology of stir-frying with vinegar Box-Behnken design-response surface method orthogonal design entropy method curcumin demethoxycurcumin bisdemethoxycurcumin |
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