| 透明质酸酶和C3F8诱导兔眼玻璃体后脱离的实验研究 |
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| 引用本文： | 叶宇峰,谢亚男,张惠成,颜伟年.透明质酸酶和C3F8诱导兔眼玻璃体后脱离的实验研究[J].医学研究杂志,2008,37(5):26-29. |
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| 作者姓名： | 叶宇峰 谢亚男 张惠成 颜伟年 |
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| 作者单位： | 1. 杭州市第一人民医院,310006
2. 杭州师范大学医学院 |
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| 摘 要： | 目的 研究透明质酸酶联合C3F8玻璃体腔注药诱导兔眼玻璃体后脱离(PVD)的效果及安全性.方法 12只兔(24只眼)随机分A、 B、 C 3组,每组4只,每兔一眼为实验眼,另一眼为对照眼.A组实验眼玻璃体腔注射0.2ml(10U)透明质酸酶,B组为0.2m1C3F8, C组为0.1ml(10U)透明质酸酶 0.1mlC3F8,对照眼玻璃体腔注入0.2ml BSS溶液.注射后常规裂隙灯、直接眼底镜及眼部B超检查.在2周后处死动物,眼球标本送光镜、扫描电镜和透射电镜检查.结果 C组4只实验眼在术后2周时B超有完全性玻璃体后脱离表现,扫描电镜也表现为较光滑的后极部视网膜表面;A组、B组及对照组眼B超检查无玻璃体后脱离表现,扫描电镜示视网膜表面较多纤维状附着物.各实验组及对照组光镜及透射电镜检查未发现视网膜组织有毒性改变.结论 10IU透明质酸酶联合0.1mlC3F8玻璃体腔注药2周后可诱导兔眼完全性玻璃体后脱离的发生,且形态学上无视网膜毒性表现.
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| 关 键 词： | 玻璃体后脱离 透明质酸酶 C3F8动物模型 兔 透明质酸酶 兔眼 玻璃体 实验组 研究 Induced Rabbits Detachment Vitreous Posterior Study 视网膜毒性 形态学 发生 视网膜组织 发现 附着物 纤维状 对照组 膜表面 |
Experimental Study of Posterior Vitreous Detachment in Rabbits Induced by Hyaluronidase and Perfluoropropane (C3F8) |
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| Ye Yufeng,Xie Yanan,Zhang Huicheng,Yan Weinian.Experimental Study of Posterior Vitreous Detachment in Rabbits Induced by Hyaluronidase and Perfluoropropane (C3F8)[J].Journal of Medical Research,2008,37(5):26-29. |
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| Authors: | Ye Yufeng Xie Yanan Zhang Huicheng Yan Weinian |
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| Affiliation: | Ye Yufeng,Xie Yanan,Zhang Huicheng,Yan Weinian.Department of Ophthalmology,Hangzhou First People\'s Hospital,Zhejiang 310006,China |
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| Abstract: | Objective To evaluate the effectson experimental posterior vitreous detachment(PVD) induced by intravitrous injection of hyaluronidase and perfIuoroethane(C3F8),and whether it is safe or not.Methods Twelve rabbits(24 eyes) were divided into 3 experimental groups,the contralateral eyes in same animals served as the controls.The eyes in group A(4 eyes) and B(4 eyes) were injected with 10IU of hyaluronldase(0.2ml) and 0.2ml perfluoropropane(C3F8) respectively.The eyes in group C(4 eyes) were received vitreous ... |
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| Keywords: | Posterior vitreous detachment Hyaluronidase perfluoropropane gas C3F8 Disease models Animal Rabbit |
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