VCAM－1与胃癌关系分析

目的：研究胃癌瘤体中血管细胞粘附分子（VCAM－1）的表达对胃癌的生长，转移的影响及与病理参数之间的关系。方法：对41例胃癌瘤体，瘤旁(2cm)及正常胃组织标本，8例良性胃溃疡，10例正常人标本进行了VCAM－1免疫组化染色，图像分析，分析VCAM－1的表达情况。结果：41例胃癌瘤体中有31例VCAM－1阳性表达，瘤旁组织2cm有5例阳性表达，正常组织5cm有4例阳性表达（P＜0．001）。胃良性溃疡8例标本中有2例阳性表达，正常对照10例中有2例阳性表达。胃癌组与溃疡组及正常组VCAM－1的阳性表达差异显（P＝0．0006），溃疡组与正常组之间无显性差异（P＝0．75）。有淋巴结转移的28例中，VCAM－1阳性表达26例，淋巴结转移阴性的11例中有5例VCAM－1阳性表达（P＝0．007）。VCAM－1的表达率及表达强度与胃癌的，分级及浸润深度相关，而与肿瘤的部位，大小无关。结论：VCAM－1表达与胃癌的发生有相关性，VCAM－1可能与胃癌的转移有关。

The correlation between vascular cell adhesion molecule-1 and gastric carcinoma

To detect the expression of VCAM 1 (vascular cell adhesion molecule 1)in gastric cancer,its adjacent tissues, gastric ulcer and normal tissues, and the correlation of expression of VCAM 1 with tumor growth,metastasis, pathological parameters.Methods: Specimens from 41 gastric cancer patients(cancer, adjacent cancer and normal tissue),8 peptic ulcer,10 normal peoples were stained, image analysis with the methods of immunohistochemistry.The relation of the data collected with clinic and pathology of gastric cancer was studied. The correlation of VCAM 1 expression and pathological characteristics of gastric cancer were studied.Results: VCAM 1 was expressed not only in vascular endothelial cells, but also in most gastric cancer cells, thirty one out of forty one cancer had the expression of VCAM 1,adjacent cancer(2cm) had 5 positive VCAM 1 and adjacent cancer(5cm) had 4 positive VCAM 1(P<0 001). Two out of 8 tissue in patient with gastric ulcer had the expression of VCAM 1,and there were 2 positive VCAM 1 in 10 normal tissue. The expression of VCAM 1 in the patients with gastric cancer was significantly higher than in the control group and ulcer group(P<0 01),no differences were noted in the control group and ulcer group. (P=0 75).Conclusion: VCAM 1 is linked with the growth of gastric cancer, and VCAM 1 expression is correlated to metastasis of gastric cancer.