脊髓损伤动物模型的研究进展

脊髓损伤是一种严重的神经系统损伤,其致残率和致死率较高。随着交通及建筑业的发展,脊髓损伤的发病率逐年增高,其病理生理机制复杂,临床治疗效果不佳,给家庭和社会带来沉重负担。为进一步认识脊髓损伤的发病机制,提高临床救治水平,有必要对脊髓损伤动物模型研究进行不断完善与发展。目前已有挫伤型、压迫型、缺血损伤型、横断损伤型、牵拉损伤型等多种动物模型,但没有一种模型能完全模拟临床脊髓损伤的病理生理过程,无法精确控制脊髓损伤的程度和范围。为了更好的研究脊髓损伤的发病机制及修复方式,脊髓损伤动物模型需具有临床相似性、可重复性、可调控性。为合理制作与临床各类脊髓损伤发病机制更为接近的脊髓损伤动物模型提供参考,该文就脊髓损伤动物实验模型的研究进展予以综述。 

Comparison of the effects of micro-locking plate and headless compression screw in oblique fracture of the medial malleolus

Spinal cord injury is a serious injury of the nervous system.It results in higher disability and mortality.With the development of transportation and construction industry,the incidence of spinal cord injury is increasing year by year.Because the pathological and physiological mechanism of spinal cord injury is complex,the effect of treatment is bad and it brings heavy burden to the family and the society.In order to further understand the pathogenesis of spinal cord injury and improve the level of clinical treatment,it is necessary to develop the research of animal model of spinal cord injury.At present,there are various animal models,such as contusion model,compression model,ischemic injury model,transection injury model,distraction model and so on.As it is unable to precisely control the degree and range of spinal cord injury,no one can completely simulate the clinical pathogenesis of spinal cord injury.In order to study the pathogenesis of spinal cord injury and the methods of repairing,the animal model of spinal cord injury should have clinical similarity,repeatability and regulation.For providing the reference for choosing appropriate model and making the models more closed to the clinical pathogenesis of spinal cord injury,in this paper,the research progress of animal models of spinal cord injury is to be reviewed.