美托洛尔对缺血性心力衰竭大鼠心肌细胞凋亡的影响

目的：探讨美托洛尔对心力衰竭（心衰）大鼠心肌细胞凋亡的影响。方法：构建心衰大鼠模型，随机分为心衰组、美托洛尔组（各15只）及假手术组（n=15），为同期开胸，无血管结扎，8周后，测定血流动力学指标，观察左右心室质量指数（LVMI．RVMI），TUNEL法检测心肌细胞凋亡率。结果：①与假手术组比较，心衰组血流动力学指标明显恶化，LVMI和RVMI显著升高，心肌细胞凋亡率增加；②与心衰组比较，美托洛尔组，MBP和LVEDP下降，±dp／dtmax均升高，LVMI和RVMI下降，心肌细胞凋亡率下降。结论：美托洛尔能抑制心肌细胞凋亡，改善心功能，逆转心室重构。

Effect of Metoprolol on Cardiomyocyte Apoptosis in Rats With Myocardial Infarction

Objective： To explore the effect of metoprolol on cardiomyocyte apoptosis in rats with heart failure. Methods： Rat models with heart failure were established and randomly divided into heart failure group （n = 15）, metoprolol group （n = 15）, and sham-operation group （n = 15）. Hemodynamic parameters, left and right ventricular mass index （LVMI, RVMI） were observed, and cardiomyocyte apoptosis were detected by the method of TUNEL in each group after 8 weeks. Results： ① Compared with those of sham operation group, hemodynamie parameters were deteriorated, LVMI and RVMI were elevated significantly and cardiomyocyte apoptosis was increased in heart failure group. ② Compared with those of heart failure group, MBP, LVEDP were descended, ± dp/dtmax elevated, LVMI and RVMI was descended, cardiomyocyte apoptosis decreased in metoprolol group. Conclusions： Metoprolol can inhibit cardiomyocyte apoptosis, improve heart function and reverse ventricular remodeling.