聚乙二醇单甲醚-聚谷氨酸的合成与表征

以聚乙二醇单甲醚为原料在溶剂中与萘钾反应．形成聚乙二醇单甲醚的钾盐活性中间体．再与对甲苯磺酰氯反应得到聚乙二醇单甲醚对甲苯磺酸酯，进而反应生成氨基聚乙二醇单甲醚，并用此引发γ-苄基-L-谷氨酸-N-羧酸酐，生成嵌段共聚物聚乙二醇单甲醚-聚苄酯谷氨酸，然后用碱脱去苄酯保护基，得到水溶性的聚乙二醇单甲醚-聚谷氨酸。用红外光谱，核磁共振，凝胶渗透色谱对聚合物结构进行了表征。该嵌段共聚物在药物控制释放研究中具有重要的应用价值。

Synthesis and Characterizations of Poly (ethylene glycol)-block-poly (glutamate)

Amine-terminated poly (ethylene glycol) (PEG) was prepared by two steps. Firstly, potassium naphthalene was added to a solution of methoxypolyethylene glycol 5,000 in benzene until the solution maintains green in half of an hour, then excess tosylchloride was introduced; secondly, the conversion of the tosylate into an amine was carried out by Gabriel synthesis. The block copolymer poly (ethylene glycol)-co-poly (gamma-benzyl L-glutamate ) could be obtained by ring-opening polymerization of gamma-benzyl-L-glutamate N-carboxy anhydride with amine-terminated PEG as macroinitiator. And the benzyl group could be removed by sodium hydroxide. The product structure was characterized by IR, 1HNMR, GPC. The cisplatin-loaded micelle was observed by transmission electron microscope (TEM). And the block copolymer is expected to be useful as functional materials including carrier systems in drug controlled delivery applications.