丹参对低温保存小肠的保护作用

目的:观察丹参对低温保存小肠的保护作用。方法:23只杂种猪分成4组,Ⅰ组(6只),Euro-collins(EC)液保存供肠;Ⅱ组(5例),获取小肠前供体给予复方丹参注射液1.0ml/kg;Ⅲ组(6例),EC液 丹参注射液(20ml/L)保存供肠;Ⅳ组(6例),EC液保存供肠,血管再通时受体给予丹参注射液(1.0ml/kg),供肠保存24小时后自体移植。结果:Ⅱ、Ⅲ组移植小肠组织损伤轻,肠粘膜能量物质(ATP)含量、Na~ -K~ ATP酶和肠粘膜双糖酶活性高于Ⅰ、Ⅳ组小肠。结论:丹参具有减轻低温保存小肠组织损伤的作用。

The Protective Effect of Salvia Miltior-rhiza on Small bowel Autograft Preserved by Cold Storage

To investigate the protective effect of salvia miltiorrhiza (SM) on small bowel autograft preserved by cold storage,23 outbred pigs were divided into 4 groups. In group 1 (n = 6), graft was preserved with Eurocollins (EC) solution, in group 2 (n = 5), donor prelreated with compound SM injection (1. 0 ml/ kg), in group 3 (w = 6), graft preserved with EC solution containing compound SM injection (20 ml/L), in group 4(n = 6).the recipient given compound SM injec-tion (1.0ml/kg). The graft was autotransplanted after 24 h storage. The Results showed Mucosal ATP content and Na - K ATPase and disccharidase activity of graft were higher in groups 2 and 3 than in groups 1 and 4. It was concluded that SM attenuated tissue injury of small bowel grafts mediated by cold storage.