| 微波促进Fries重排反应合成(2-羟基-5-甲基)苯基-1-十二酮 |
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| 引用本文： | 袁淑军,吕春绪,蔡春.微波促进Fries重排反应合成(2-羟基-5-甲基)苯基-1-十二酮[J].精细化工,2004,21(3):230-231,237. |
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| 作者姓名： | 袁淑军 吕春绪 蔡春 |
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| 作者单位： | 1. 南京理工大学,化工学院,江苏,南京,210094;盐城工学院,化工系,江苏,盐城,224003
2. 南京理工大学,化工学院,江苏,南京,210094 |
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| 摘 要： | 在连续微波照射下,由十二酸对甲酚酯的Fries重排反应合成了(2 羟基 5 甲基)苯基 1 十二酮。通过对不同的溶剂、催化剂和反应时间的探索,发现与经典的反应相比,微波促进的反应在120℃下以硝基苯为溶剂、无水三氯化铝作催化剂时,反应时间由2h缩短到8min,收率由89 5%提高到93 4%。
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| 关 键 词： | 微波照射 Fries重排 高级脂肪酸酚酯 (2-羟基5-甲基)苯基-1-十二酮 |
| 文章编号： | 1003-5214(2004)03-0230-03 |
Synthesis of (2-Hydroxy-5-methyl)phenyl-1-dodecanone by Microwave-enhanced Fries Rearrangement |
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| YUAN Shu-jun.Synthesis of (2-Hydroxy-5-methyl)phenyl-1-dodecanone by Microwave-enhanced Fries Rearrangement[J].Fine Chemicals,2004,21(3):230-231,237. |
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| Authors: | YUAN Shu-jun |
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| Affiliation: | YUAN Shu-jun~ |
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| Abstract: | The Fries rearrangement of 4-methylphenyl dodecanoate was carried out under continuous microwave irradiation to form (2-hydroxy-5-methyl)phenyl-1-dodecanone.The reaction was steadily performed at 120 ℃ when nitrobenzene was used as the solvent and AlCl_3 as the catalyst.Compared with the classical method,yield of the reaction under microwave irradiation was raised from 89.5% to 93.4%,meanwhile the reaction time was shortened from 2 h to 8 min. |
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| Keywords: | microwave irradiation Fries rearrangement higher aliphatic phenol ester (2-hydroxy-5-methyl)phenyl-1-dodecanone |
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