实验性动脉粥样硬化家兔血浆LPO与红细胞SOD,GSH—Px的活力观察

为了研究自由基在动脉粥样硬化过程中的作用,建立了家兔动脉粥样硬化模型。实验组随着TC,LDL-C的升高,LPO由0.30上升到2.12△D_(233)/ml,是对照组的14倍。TC,LDL-C与LPO呈明显正相关(r=0.69,r=0.67,P<0.05)。但是,随着LPO的上升,GSH-Px逐渐下降,是对照组的0.57,0.35倍。SOD在两组间差异无显著性(P>0.05)。结果表明,检测LPO和GSH-Px对由于动脉粥样硬化引起的心脑血管病的诊断、疗效评估和预后有重要意义。

STUDY OF THE ACTIVITY OF PLASMA LPO, RBC-SOD, GSH-Px ON EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS

AS model in rabbits was established for studying the function of free redical. The results showed, that the plasma cholesterol, LDL-cholesterol were rising in experimental group, plasma LPO was elevated from 0.3 to 2.12 AD_(233)/ml. It was 14 times high as that in the control group. There were positive correlation between cholesterol, LDL-cholesterol and LPO (r=0.690, r=0.669, P<0.05). But RBC-G SH-Px were lowered by degrees, which is 0.57 times (45 days) and 0.35 times (0.75 days) lower than that in the control group with the elevation of LPO. The results showed, that SOD presented no significant difference experimental group and control group (P>0.05) . It was suggested, that the detections of LPO and GSH-Px play an important role in diagnosis and evaluating the efficacy of treatment for cardiocercbrovascular disease.