| 阿立哌唑与利培酮治疗精神分裂症的对照研究 |
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| 引用本文： | 胡亚湘,崔炳喜,于浚玫,崔鹏,秦颖.阿立哌唑与利培酮治疗精神分裂症的对照研究[J].天津药学,2010,22(1):41-43. |
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| 作者姓名： | 胡亚湘 崔炳喜 于浚玫 崔鹏 秦颖 |
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| 作者单位： | 天津市安定医院,天津,300222 |
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| 摘 要： | 目的：比较阿立哌唑与利培酮治疗精神分裂症的疗效和安全性。方法：对符合《中国精神障碍分类与诊断标准》第3版（CCMD-3）精神分裂症诊断标准的50例患者，随机分为两组，分别给予阿立哌唑和利培酮治疗共8周。采用阳性与阴性症状量表（PANSS）和不良反应量表（TESS）评分。结果：治疗8周后阿立哌唑组和利培酮组的显效率分别为72％和76％，差异无显著性（P〉0．05）。两组治疗后各时点PANSS总分及各因子分也无显著性差异（P〉0．05）。阿立哌唑组的主要不良反应为恶心，厌食，呕吐等消化道症状，而锥体外系反应明显低于利培酮组。结论：阿立哌唑和利培酮对精神分裂症疗效相当，不良反应轻，均为疗效好的抗精神病药，阿立哌唑更适合于锥体外系副作用不能耐受的患者。
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| 关 键 词： | 阿立哌唑 利培酮 精神分裂症 不良反应量表 |
Comparison of aripiprazole and risperidone in patients with schizophrenia |
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| Hu Yaxiang,Cui Bingxi,Yu Junmei,Cui Peng,Qin Ying.Comparison of aripiprazole and risperidone in patients with schizophrenia[J].Tianjin Pharmacy,2010,22(1):41-43. |
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| Authors: | Hu Yaxiang Cui Bingxi Yu Junmei Cui Peng Qin Ying |
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| Affiliation: | Hu Yaxiang,Cui Bingxi,Yu Junmei,Cui Peng,Qin Ying(Tianjin ,ing Hospital,Tianjin 300222) |
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| Abstract: | Objective:To compare the efficacy and safety of aripiprazole and risperidone in patients with schizophrenia.Methods:50 adult patients with the disease conforming to the CCMD-3 Diagnostic Criteria for Schizophrenia were randomly allocated to the aripiprazole group(n=25) or the risperidone group(n=25).The subjects were given aripiprazole and risperidone respectively for eight weeks.Positive and Negative Syndrome Scale(PANSS)and Treatment Emergent Side effect Scale(TESS)were used for the evaluation of the effi... |
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| Keywords: | aripiprazole risperidone schizophrenia adverse drug effects |
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