人参皂甙Rg1对内毒素性肺损伤血管通透性的影响

目的:探讨人参皂甙Rg1(ginsenosideRg1)对脂多糖(LPS)所致大鼠急性肺损伤(ALI)后肺血管通透性的影响,比较地塞米松(Dex)、人参皂甙对ALI的疗效。方法:将大鼠随机分成对照组、LPS组、Dex+LPS组、Rg1+LPS组,对各组大鼠的肺系数、肺水含量、肺通透指数、肺血管通透性、PO2、PCO2、pH值等指标进行观测,同时将肺组织送病理检查,并进行病理评分。结果:Rg1组的肺系数、肺水含量、肺通透指数、PCO2和病理评分均显著低于LPS组(P<0.01),但高于对照组(P<0.01),其PO2、pH值显著高于LPS组(P<0.01),但低于对照组(P<0.01),Dex+LPS组的肺系数、肺水含量、肺通透指数、PO2、pH值、PCO2和病理评分与Rg1+LPS组相比差异无显著性(P>0.05)。结论:人参皂甙Rg1可降低肺水肿参数,改善肺组织水肿,降低肺血管通透性,作用与Dex类似,其具体作用机制需进一步研究。

Effects of ginsenoside Rg1 on pulmonary vascular permeability in acute lung injury induced by lipopolysaccharide

Objective To observe the protective effects of ginsenoside Rg1 on pulmonary vascular permeability in acute lung injury(ALI) induced by lipopolysaccharide(LPS) in rats. Mothods Animals were divided randomly into 4 groups as follows: control group(n=8), LPS group(n=8), LPS plus dexamethasone(Dex) group(n=8) and LPS plus Rg1 group(n=8). samples of arterial blood, serum, lung tissue and the bronchoalveolar lavage fluid(BALF) were collected after 6 hours. The levels of lung index, lung water, lung penetrating index(LPI), lung vasopermeability were mesured and arterial blood gas were analysed. The pathological changes of rat' s lung were observed and scored down. Results Compared with the LPS group, lung index, lung water, lung penetrating index, lung vasopermeability, PCO2, and pathology score in Rg1 group decreased significantly(P< 0.01) but higher than those in control group(P< 0.01) and as same as those in Dex group. Conclution Ginsenoside Rg1 has protective effects on pulmonary vascular permeability in acute lung injury induced by endotoxic shock.