1.Wuxi school of medicine, Jiangnan University, Wuxi 214122, China2.Public Health Research Center, Jiangnan University, Wuxi214122, China3.Department of Liver Disease, Wuxi No.5 People’s Hospital affiliated to Jiangnan University, Wuxi 214073, China4.Department of Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China#These authors contributed equally to this work.
Abstract:
Anelloviruses are single-strand circular DNA viruses and ubiquitous within the human population. Although there is no direct evidence, many studies have suggested the anelloviruses may be associated with a variety of diseases. In this study, a novel torque teno mini virus (TTMV) was detected in a child with unexplained encephalitis. The detected virus had a circular genome of 2943 nt in length and 3 open reading frames. It shared 45.4% – 35.9% nucleotide identities with known TTMV species and < 35% with the other species of anellovirus, which suggested it might belong to a new species within the genus Betatorquevirus. Phylogenetic analysis based on the amino acid sequences of ORF1 showed that this virus represented a distinct branch within the diversity of anellovirus. Whether this novel anellovirus strain is associated with encephalitis requires further study.
