The association of oxidant–antioxidant status in patients with chronic renal failure |
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| Authors: | Manal A Aziz Ghanim H Majeed Kareem S Diab Raid J Al-Tamimi |
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| Affiliation: | 1. Pharmacology Department, Institute of Medical Technology, Almansur, Baghdad, Iraq,;2. Health and Medical Technology College, Baghdad, Iraq,;3. Al-Nahrain Medical College, Baghdad, Iraq |
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| Abstract: | Oxidative stress has been linked to disease progression, including chronic renal failure (CRF). The aim of the present study was to determine malondialdehyde (MDA) as a sign of lipid peroxidation, and to investigate the association between antioxidant activities and three trace elements, in 49 patients with CRF. The erythrocyte and plasma trace elements selenium (Se), zinc (Zn), and copper (Cu)] and antioxidant defense levels were determined: glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), vitamins E and C. The obtained values were compared with 42 age- and sex-matched healthy controls. There were significantly lower mean values of plasma Se, GPx, vitamins E and C, erythrocyte Se, SOD and CAT levels in the patient group compared to the control group (p?
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| Keywords: | Antioxidants oxidative stress trace elements lipid peroxidation chronic renal failure |
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