眼针对血管性痴呆大鼠学习记忆障碍及血液流变的影响

目的:探讨眼针对血管性痴呆(VD)大鼠学习记忆障碍及血液流变的影响。方法:4—血管阻断法制成血管性痴呆大鼠模型。取眼针肝区、心区、肾区。共治疗30天,并与西药尼莫通相对照。实验前后分别进行Y—型迷宫测试及实验结束后腹主动脉取血测量血液流变各项指标。结果:与对照组比较,模型组大鼠学习记忆明显障碍,眼针组、尼莫通组学习记忆能力明显改善,与模型组比较(P<0.01)。模型组与对照组相比,全血黏度、血浆黏度、红细胞压积及纤维蛋白原浓度升高,P<0.01。眼针组、尼莫通组与模型组相比,全血黏度、血浆黏度、红细胞压积及纤维蛋白原浓度降低,P<0.01~0.05。结论:眼针能改善血管性痴呆(VD)大鼠学习记忆障碍及血液流变的各项指标。

Effects of Eye Acupuncture on Learning Disorder and Dysmnesia, and Blood Rheologic Characteristics in the Rats with Vascular Dementia

Objective:To investigate the effects of eye acupuncture on learning disorder and dysmnesia,and blood rheologic characteristics in rats with vascular dementia.Methods:A rat model of vascular dementia was made by 4–vessel occulusion.The liver,heart and kidney areas were selected for eye acupuncture.The treatment lasted 30 days.Western medicine Nimoton was used as a control.A Y type maze test and the blood rheologic characteristics was performed before and after the experiment.Results:Learning disorder and dysmnesia were obvious in the model group as compared with the control group as compared with the control group.In the eye acupuncture and medication group of vascular dementia rats,learning disorder and dysmnesia were significantly abated as compared with the model group(P<0.01).Compared with the rheologic characteristics of model and control group,the modeling group's blood became densier and sticker(P<0.01).In the eye acupuncture and medication groups of vascular dementia rats,the blood became fluencier,and the changes of the blood rheologic characteristics were significantly abated as compared with model group(P<0.01～0.05).Conclusion:Eye acupuncture can produce an improving effect on learning disorder and dysmnesia,and changes the blood rheologic characteristics in experimental vascular dementia rats.