| 丹酚酸B/三七总皂苷配伍对心肌梗死大鼠左室结构和功能的影响 |
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| 作者单位： | 天津中医药大学，天津中医药大学，天津中医药大学，天津中医药大学第二附属医院，天津中医药大学 |
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| 摘 要： | 目的]研究丹酚酸B(SalB)、三七总皂苷(PNS)对心肌梗死大鼠左室结构和功能的影响,探讨中药组分配伍的作用。方法]结扎冠脉左前降支复制大鼠心肌梗死模型,假手术组作对照,连续灌胃给药7d。用彩色超声心动仪观察心脏左室结构和功能变化。结果]SalB、PNS以及配伍组可以不同程度地降低左室收缩末期内径(LVDs)、左室收缩末期容积(LVESV),升高左室射血分数(EF)、左室短轴缩短率(FS),配伍组有优于其他中药组的趋势。结论]SalB、PNS配伍可以有效改善心肌梗死大鼠的左室结构和功能。
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| 关 键 词： | 丹酚酸B 三七总皂苷 配伍 左心室 心肌梗死 |
Effect of the combination of Sal B and PNS on left ventricular construction and function of rats with myocardial infarction |
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| Authors: | ZHANG Meng GAO Xiu-mei WANG Yi |
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| Abstract: | Objective] In order to elucidate the scientific connotation of compatibility in traditional Chinese medicine (TCM) formulas, we observed the effects of Salvianolic acid B (Sal B) and panax notoginseng saponins (PNS) used alone and in combination on rats with acute myocardial infarction. Methods] To produce myocardial infarction in anaesthetized rats by occluding the left descending coronary artery. Sham-operated rats served as controls. To assayed the construction and function of left ventricular by using echocardiography. Results] Sal B, PNS and the combination of Sal B and PNS can decrease LVDs, LVESV and increase EF and FS. There was a trend that the effects of the combination of Sal B and PNS were better than others. Conclusion] The combination of Sal B and PNS can improve the heart function effectively. |
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| Keywords: | Salvianolic acid B panax notoginseng saponins compatibility left ventricular myocardial infarction |
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