胆管癌发生与发展的相关基因调控的研究

胆管癌是一种胆管常见的恶性肿瘤,临床上外科根治性切除率低,预后差。近年来随着对胆管癌发病机制研究的不断深入,人们开始从基因水平探索胆管癌的发生和发展机制。已发现胆管癌的发生可能由于ras通路、RB通路等多个信号转导通路中多种基因的点突变、缺失和过度表达,同时伴有多个抑癌基因的共同甲基化。而胆管癌的转移与nm23基因和mammaglobin B基因的过表达有密切联系,同时整合素、CD44等也参与了癌转移的过程。

Genes and Cholangiocarcinoma Genesis and Development

Cholangiocarcinoma is a common kind of bile duct malignant tumour,its low surgical radical resection lead to bad prognosis.Along with the continuous deepening of the research into the pathogenesis of cholangiocarcinoma,people are working on a gene level.It has been discovered that the occurrence of cholangiocarcinoma might be caused by the point mutations,deletions and overexpression of multiple genese in ras pathway,RB pathway,which are accompanied by multiple tumor suppressor gene methylation.Metastasis of cholangiocarcinoma is closely associated with overexpression of gene nm23 and mammaglobin B,while integrin,CD44 are also involved in the process of metastasis.