铁皮石斛中一个新化合物

 目的 研究铁皮石斛的化学成分。方法 采用硅胶色谱法、HP₂MGL型大孔树脂色谱法、Sephadex LH-20、Sephadex G-25凝胶色谱法、RP-HPLC制备柱色谱法进行分离纯化，通过现代波谱技术进行结构鉴定。结果 鉴定了10个化合物，分别为2-甲氧基苯基-1-O-β-D-芹糖-(1→2)-β-D-葡萄糖苷(1)， 3，4，5-三甲氧基苯基-1-O-β-D-芹糖-（1→2）-β-D-葡萄糖苷(2)， leonuriside A（3），(1′R)-1′-(4-羟基-3，5-二甲氧基苯基)-1-丙醇-4-O-β-D-葡萄糖苷（4），左旋丁香脂素（5），丁香脂素-4，4′-O-双-β-D-葡萄糖苷（6），(+)-丁香脂素-4-O-β-D-吡喃葡萄糖苷（7），icariol A₂-4-O-β-D-glucopyranoside（8），(+)-lyoniresinol-3a-O-β-D-glucopyranoside（9），裂异落叶松脂醇（10）。结论 1为新化合物，2～4，6～10为首次从本属植物中发现，5为首次从本植物中发现。

A New Compound from Dendrobium candidum

OBJECTIVE To study the chemical constituents of Dendrobium candidum. METHODS The compounds were isolated and purified by repeated column chromatography with silica gel， HP₂MGL macroporous resin， Sephadex LH-20， Sephadex G-25 and RP-HPLC. Their structures were identified by spectroscopic data. RESULTS Ten compounds were isolated from Dendrobium candidum， and identified as 2-methoxyphenol-O-β-D-apiofuromosyl-(1→2)-β-D-glucopyranoside (1)， khaephuouside (2)， leonuriside A (3)， (1′R)-1′-(4-hydroxy-3，5-dimethoxylphenyl) propan-1′-ol 4-O-β-D-glucopyranoside (4)， (-) syringaresinol (5)， syringaresinol-4，4′-O-bis-β-D-glucoside (6)， (+)-syringaresinol-4-β-D-monoglucoside (7)， icariol A₂-4-O-β-D-glucopyranoside (8)， (+)-lyoniresinol-3a-O-β-D-glucopyranoside (9) and (-)-secoisolariciresinol (10). CONCLUSION Compoud 1 is a new compound， compound 5 was isolated from Dendrobium candidum for the first time， and others were isolated from the Dendrobium species for the first time.