| Enalapril对实验性糖尿病大鼠肾脏的保护作用机理研究 |
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| 引用本文： | 傅静奕,田浩明,梁荩忠.Enalapril对实验性糖尿病大鼠肾脏的保护作用机理研究[J].四川大学学报(医学版),2001,32(1):80-82. |
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| 作者姓名： | 傅静奕 田浩明 梁荩忠 |
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| 作者单位： | 华西医科大学附属第一医院内分泌科 |
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| 摘 要： | 目的 研究血管紧张素转换酶抑制剂 Enalapril对糖尿病的肾病治疗作用机理。方法 以Enalapril治疗实验性糖尿病大鼠 ,并将正常组、糖尿病对照组及治疗组尿蛋白水平及肾组织转化生长因子 β、糖基化终末产物含量进行比较。结果 Enalapril治疗组大鼠肾组织转化生长因子 β及糖基化终末产物含量与糖尿病对照组相比无下降。结论 Enalapril的肾脏保护作用并非通过抑制肾组织转化生长因子 β上调或糖基化终末产物积聚
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| 关 键 词： | 糖尿病肾病 Enalapril 转化生长因子-β 糖基化终末产物 血管紧张素转化酶抑制剂 |
| 修稿时间： | 2000年10月25 |
The Mechanism of Protective Effects of Enalapril on Experimental Diabetic Nephropathy of Rats |
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| Fu Jingyi,Tian Haoming,Liang Jinzhong.The Mechanism of Protective Effects of Enalapril on Experimental Diabetic Nephropathy of Rats[J].Journal of West China University of Medical Sciences,2001,32(1):80-82. |
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| Authors: | Fu Jingyi Tian Haoming Liang Jinzhong |
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| Affiliation: | Fu Jingyi,Tian Haoming,Liang Jinzhong. Department of Endocrinology,The First Affiliated Hospital,WCUMS,Chengdu 610041,China |
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| Abstract: | Objective To elucidate the mechanisms of renoprot ective effectsof ACEI on diabetic animals and patients. Methods STZ-induced diabetic rats were treated with Enalapril and the levels of urine protein, TGF-β and AGEs in renal tissue were measured and compared. R esults The results of TGF-β quantitation and AGE fluorescence of Enal april treatment group rats were the same as those of diabetic control rats. Conclusion Suppression of TGF-β overexpression or AGEs accumulati on was not implicated in the mechanisms of renoprotective effects of ACEI. |
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| Keywords: | Enalapril |
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