| 2，2＇-联咪唑硝基衍生物的合成及与DNA相互作用的研究 |
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| 引用本文： | 杨莉宁,姚琳,余丽丽,杨黎燕,尤静.2，2＇-联咪唑硝基衍生物的合成及与DNA相互作用的研究[J].湖北化工,2012(7):56-59. |
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| 作者姓名： | 杨莉宁 姚琳 余丽丽 杨黎燕 尤静 |
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| 作者单位： | 西安医学院药学院,陕西西安。710021 |
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| 摘 要： | 基于硝基咪唑类化合物有着广泛的抗微生物活性，合成了2，2L联咪唑的单硝基N02Hbiim和二硝基（N02）：biim两种衍生物，通过元素分析、紫外光谱、红外光谱、热重分析对其进行了表征，并采用紫外光谱法、荧光光谱法和粘度法研究了二者与小牛胸腺DNA（ct-DNA）的相互作用。结果表明，化合物结构的共平面性对其与DNA的插入作用有较大的影响。
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| 关 键 词： | 2，2’-联咪唑硝基衍生物 小牛胸腺DNA 构效关系 |
Study on Synthesis of Nitroderivatives of 2,2 ＇-Bnmldazole and Their Interaction with DNA |
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| YANG Li-ning,YAO Lin,YU Li-li,YANG Li-yan,YOU Jing.Study on Synthesis of Nitroderivatives of 2,2 ＇-Bnmldazole and Their Interaction with DNA[J].Hubei Chemical Industry,2012(7):56-59. |
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| Authors: | YANG Li-ning YAO Lin YU Li-li YANG Li-yan YOU Jing |
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| Affiliation: | (Department of Pharmacy ,MedicaZ University of Xi＇an , Xian 710021, China) |
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| Abstract: | In view of the nitroimidazole compounds having antimicrobic activity in a wide range, two nitro- derivatives of 2,2＇-biimidazole,NOz Hbiim and （NOz）zbiim, had been synthesized and characterized by elemental analysis, UV, IR and TG-DSC. The binding of the compounds with calf thymus DNA were investigated by UV, fluorescence spectrum and viscosity measurement. The results indicated that the coplanarity of the com- pound structure had a greater impact on its insertion into DNA. |
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| Keywords: | nitroderivatives of 2 2＇-biimidazole calf thymus DNA（ct-DNA） structure-activity relationship |
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