| 强效降眼内压药—安普乐定的合成方法探讨 |
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| 引用本文： | 白少岩,杨尚军,唐文照.强效降眼内压药—安普乐定的合成方法探讨[J].齐鲁药事,2004,23(5):46-47. |
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| 作者姓名： | 白少岩 杨尚军 唐文照 |
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| 作者单位： | 山东省医学科学院药物研究所,济南,250062 |
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| 摘 要： | 目的 探讨安普乐定的合成方法。方法 采用对硝基苯胺为原料,经还原、加保护基、甲酰化、氯化、环合、脱保护基六步反应法可进行化学合成。结果及结论 该合成方法所需试剂安全易得,合成条件平和,适于工业化生产。
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| 关 键 词： | 安普乐定 合成 |
| 文章编号： | 1672-7738(2004)05-0046-02 |
Research on the synthesis of potent decreasing IOP drug Apraclonidine |
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| Bai Shao-yan,Yang Shang-jun,Tang Wen-zhao.Research on the synthesis of potent decreasing IOP drug Apraclonidine[J].qilu pharmaceutical affairs,2004,23(5):46-47. |
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| Authors: | Bai Shao-yan Yang Shang-jun Tang Wen-zhao |
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| Abstract: | Objective To research the synthesis method of Apraclonidine. Methods Apraclonidine was synthesized from P-Nitraniline by reaction with reduction, adding protection group, formylation, chlorination, cyclization, off-protecting group. Results andconclusion The raw materials were safe and cheap. The reaction conditions were mild. Therefore the industrialization of productioncould be achieved by this method. |
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| Keywords: | Apraclonidine synthesis |
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