脂肪乳静脉输注致2例老年患者脂肪超载综合征

例1为80岁女性患者，接受右侧肺大疱切除和胸膜摩擦固定术后，静脉输入脂肪乳连续7周。之后TBil、DBil、TG由12.5μmol／L、3．3μmol／L和0．95mmol／L升至141．5μmol／L、104．3μmoL／L和13．64mmoL／L，PLT由189×10^9／L下降至48×10^9／L。停用脂肪乳后，TBil、DBil、TG分别为46．2μmol／L、33．1μmol／L和2．50mmoL／L，PLT51×10^9／L。10d后，患者死于循环、呼吸衰竭。例2为89岁男性患者，因肺部感染、左侧气胸及水电解质紊乱，静脉输入脂肪乳连续3周。之后，TBil、DBil、TG由9．5μmol/L、4、1μmol／L和1．03mmol／L升至210．8μmol／L、182．1μmoL／L和13．96mmol／L，PLT由242×10^9／L降至128×10^9／L。停用脂肪乳后，TBil、DBil、TG分别为152．4μmol/L、89.3μmol/L和5．32mmol／L，PLT88×10^9／L。患者死于多器官功

Fat overloading syndrome following intravenous infusion of fat emulsion in two elderly patients

Patient 1, an 80-year-old woman underwent resection of bullas of the right lung and fixation of pleural friction received intravenous infusion of fat emulsion for seven consecutive weeks. Later, her TBil, DBil, and TG levels increased from 12.5 μmol/L, 3.3 μmol/L and 0.95 mmol/L to 141.5 μmol/L, 104.3 μmol/L, and 13.64 mmol/L, respectively; her PLT decreased from 189 × 10^9/L to 48 × 10^9/L. After stopping fat emulsion, her TBil, DBil, and TG levels were 46.2 μmol/L, 33.1 μmol/L, and 2.50 mmol/ L, respectively; her PLT was 51 × 10^9/L. And ten day later, the patient died of circulatory and respiratory failure. Patient 2, an 89-year-old man with pulmonary infection, left pneumothorax, and water-electrolyte disturbances received intravenous infusion of fat emulsion for three consecutive weeks. Later, his TBil, DBil, and TG levels increased from 9.5μmol/L, 4. 1μmol/L, and 1.03 mmol/L to 210.8 μmol/L, 182.1μmol/L, and 13.96 mmol/L, respectively; his PLT level decreased from 242× 10^9/L to 128× 10^9/L. After stopping fat emulsion infusion, his TBil, DBil, TG and PLT level were 152.4μmol/L, 89.3μmol/L, 5.32 mmol/L, and 88 × 10^9/L, respectively. The patient died of multiorgan failure. KEY WORDS fat emulsion; fat overloading syndrome