垂体腺瘤组织中PTTG、Survivin、P53、Ki-67的表达及其与侵袭性和复发的相关性

目的通过对垂体肿瘤转化基因(PTTG)、凋亡抑制蛋白Survivin、P53蛋白以及细胞增殖指数Ki-67在垂体腺瘤中表达情况检测和相关性分析,探讨PTTG、Survivin、P53和Ki-67指数的表达与垂体腺瘤侵袭性和复发的关系。方法将48例垂体腺瘤分为侵袭组、非侵袭组和复发组,免疫组化检测PTTG、Survivin、P53和Ki-67指数的表达,分析三组垂体腺瘤PTTG、Survivin、P53蛋白和Ki-67指数的表达差异及相互之间的相关性。结果侵袭组和复发组PTTG、Survivin和P53蛋白表达均较非侵袭组增高,差异有显著性意义(<0.05);相关性分析显示,PTTG、Survivin和P53蛋白表达相互之间均呈正相关(<0.01)。Ki-67在侵袭组、非侵袭组、复发组均有表达,各组间表达相差无显著性。结论PTTG、Survivin和P53蛋白的高表达与垂体腺瘤的侵袭性与复发密切相关。PTTG、Survivin和P53蛋白可作为预测垂体腺瘤侵袭性及可能复发的生物学指标,也可作为指导术后个体化治疗的客观参考指标。

A study of the relationship between the expressions of PTTG、Survivin and P53 and the biological behavior in pituitary adenomas

Objective To study the protein expressions of pituitary tumor transforming gene(PTTG), Survivin, P53 inpituitary neoplasms,and to explore the association between the expressions and the biological behavior in pituitary neoplasms. Methods Immunohistochemistry in 48 patients with pituitary neoplasms who were divided into invasive and recurrent and non-invasive groups. The difference in the expressions between the 3 groups and the correlation among the expressions were analyzed. Results The protein expressions of PTTG,Survivin and P53 were significantly hig-her in invasive and recurrent groups than those in non-invasive group. The positive relation was found among the protein expressions of PTTG,Survivin and P53 . Expressions of Ki-67 were significantly higher in invasive , recurrent and non-invasive groups. The nonrelation was found . Conclusions The abnomal expressions of PTTG,Survivin and P53 may have important rules in tumor genius and progressions of pituitary neoplasms and can be considered as the indicators of the invasiveness of pituitary neoplasms and individual chemotherapy.