改良性电抽搐联合利培酮治疗甲基苯丙胺所致精神障碍的对照研究

目的探讨改良电抽搐治疗(MECT)联合药物治疗甲基苯丙胺所致精神障碍患者的临床疗效及安全性。方法 84例甲基苯丙胺所致精神障碍患者随机分为联合治疗组及单纯药物组各42例,单纯药物组给予利培酮治疗,联合治疗组给予MECT合并利培酮治疗。采用阳性与阴性症状量表(PANSS)及副反应量表(TESS)评定疗效和不良反应。结果治疗一周后联合治疗组有效率为61.90%,单纯药物组有效率为38.10%,两组差异具有统计学意义(P<0.05)。治疗3周后,联合治疗组有效率为88.10%,单纯药物组有效率为85.43%,两组差异无统计学意义(P>0.05)。联合治疗组副反应较少,且消失较快。结论 MECT合并利培酮治疗甲基苯丙胺所致精神障碍起效更快,副作用小,且安全。

Comparative study of modified electroconvulsive therapy combined with risperidone in the treatment of methamphetamine-induced psychiatric disorde

Objective To evaluate clinical efficacy and safety of modified electroconvulsive treatment (m-ECT) combined with risperidone in the treatment of methamphetamine-induced psychiatric disorder. Methods Eighty-four patients with methamphetamine-induced psychiatric disorder were consecutively divided into the study group and the control group, with 42 cases in each group. Patients in the study group were treated with m-ECT combined with risperidone, while those in the control group were treated with risperidone solely, Positive and Negative Syndromes Scale (PANSS) as well as Treatment Emergent Symptoms Scale (TESS) were used to evaluate the clinical efficacy and side effects. Results After one week of treatment, the effective rates of the study group and the control group were 61.90% and 38.10%, respectively, which showed difference between the two groups (P<0.05). Eight weeks later, the effective rates of the study group and the control group were 88.10% and 85.4%, respectively, showing no difference between the two groups (P>0.05). The study group was observed with few side effects, which disappeared quickly. Conclusion in For treating of methamphetamine-induced psychiatric disorder. modified electroconvulsive treatment combined with risperidone has better efficacy and less side effects than risperidone.