抗焦虑抑郁辅助治疗对慢性阻塞性肺疾病患者临床疗效观察

目的探讨抗焦虑抑郁辅助治疗对慢性阻塞性肺疾病患者的临床疗效。方法连续性纳入2012年1月至2014年12月期间于我院住院治疗的慢阻肺急性发作患者336例,通过抑郁焦虑评分量表筛选出慢阻肺合并抑郁焦虑的患者82例,并随机分为治疗组(n=41)和对照组(n=41)。通过m MRC评分,BODE指数和CAT评分评价治疗前后慢阻肺患者病情程度改变情况。通过SAS评分和SDS评分评价治疗前后焦虑抑郁程度。结果治疗组患者治疗1月后BODE指数(3.4±1.1 vs.2.4±0.5,P0.05)和CAT评分(15.1±6.1 vs.9.2±6.6,P0.05)下降较为明显;而对照组仅CAT评分较治疗前明显下降(15.5±7.6 vs.10.1±4.6,P0.05)。治疗组治疗1月后SDS评分X值(44.6±3.1 vs.40.3±6.5,P0.05)和SAS评分Y值(53.3±4.7 vs.49.1±5.5,P0.05)下降较为明显。相关性分析提示△SAS评分(Y值)(r=0.832,P0.05)、△SAS评分(X值)(r=0.850,P0.05)和△SAS评分(Y值)(r=0.792,P0.05)与黛力新治疗呈正相关。结论小剂量黛力新干预治疗有助于改善焦虑抑郁状态,提高临床治疗。

Clinical effect of anti-anxiety and depression adjuvant treatment in patients with chronic obstructive pulmo-nary disease

Objective To evaluate the clinical effect of anti-anxiety and depression adjuvant treatment in pa-tients with chronic obstructive pulmonary disease ( COPD).Methods 82 COPD patients with anxiety or/and de-pression were selected from a total 336 COPD patients from Jan 2012 to Dec 2014.All the patients were equally and randomly divided into two groups: the treatment group (n=41) and the control group (n=41).mMRC scores, BODE index and CAT scores were used to estimate the degree of COPD after treatment .SAS scores and SDS scores were recorded to assess the degree of anxiety and depression after treatment .Results The levels of BODE index (3.4 ±1.1 vs.2.4 ±0.5) and CAT scores (15.1 ±6.1 vs.9.2 ±6.6) in the treatment group reduced significantly after treatment, while only CAT scores (15.5 ±7.6 vs.10.1 ±4.6) showed significant reduction in the control group after treatment.The levels of SDS scores X (44.6 ±3.1 vs.40.3 ±6.5), SAS scores Y (53.3 ±4.7 vs.49.1 ±5.5) in the treatment group were significantly decreased after treatment .Correlation analysis showed that △SAS scores ( Y) (r=0.832,P<0.05),△SAS scores(X) (r=0.850, P<0.05) and △SAS scores(Y) (r=0.792, P<0.05) were positively associated with deanxit treatment .Conclusion A low-dose deanxit treatment can improve the anxie-ty/depression state and increase therapeutic effect in patients with COPD .