甘丙肽对骨骼肌细胞葡萄糖转运蛋白4的影响

背景：甘丙肽能促进骨骼肌细胞葡萄糖转运蛋白4膜转位和葡萄糖清除,葡萄糖转运蛋白4是运动促进骨骼肌细胞摄取葡萄糖的主要载体,从而增加骨骼肌摄取葡萄糖而降低血糖。目的：探讨甘丙肽与胰岛素联用对糖尿病大鼠骨骼肌细胞葡萄糖转运蛋白4膜位移的作用。方法：由第一作者检索1991年1月2011年12月PubMed数据库（http：//www.ncbi.nlm.nih.gov/PubMed）及万方数据库（http：//www.wanfangdata.com.cn）。英文检索词为＂Galanin;insulin＂,中文检索词为＂甘丙肽;葡萄糖转运蛋白4＂。检索文献量总计143篇,选择甘丙肽与胰岛素在改善骨骼肌摄取葡萄糖的特点及其临床应用方面的文献,排除陈旧及重复实验文章,同一领域文献则选择近期发表或发表在权威杂志的文章,最终纳入37篇符合标准的文献。结果与结论：甘丙肽是一种广泛分布在神经系统的神经肽,具有广泛的神经生物学功能。运动能提高血浆甘丙肽浓度以及甘丙肽对2型糖尿患者的保护机制已经得到认可。甘丙肽及胰岛素都有降低血糖的功效。糖尿病是甘丙肽和胰岛素共同障碍的结果,那么甘丙肽与胰岛素联用的疗效自然成为关注的焦点,即两者联用对糖尿病大鼠骨骼肌细胞葡萄糖转运蛋白4膜位移的作用,是否比单独运用甘丙肽或胰岛素对骨骼肌细胞葡萄糖转运蛋白4膜位移的作用更强是目前研究的趋势。

Galanin effects on skeletal muscle glucose transporter protein 4

BACKGROUND：Galanin can promote skeletal muscle glucose transporter protein 4 membrane translocation and glucose clearance.Glucose transporter protein 4 is the main carrier of the movement to promote skeletal muscle glucose uptake,thereby increasing skeletal muscle glucose uptake and lowering blood sugar.OBJECTIVE：To explore the combined effect of galanin and insulin on skeletal muscle glucose transporter protein 4 membrane displacement in diabetic rats.METHODS：The first author searched PubMed database（1991-01/2011-12）（http：//www.ncbi.nlm.nih.gov/PubMed） and Wanfang Database（1991-01/2011-12）（http：//www.wanfangdata.com.cn） using the key words of ＂galanin,insulin＂ in English and ＂galanin,glucose transporter protein 4＂ in Chinese,respectively.Totally 143 papers were retrieved,and finally 37 articles were included that were related to clinical application and characteristics of galanin and insulin to improve skeletal muscle glucose uptake.Obsolete and duplicate papers were excluded,and articles published recently or in authorized journals were preferred.RESULTS AND CONCLUSION：Galanin is a widely distributed neuropeptide in the nervous system,with a wide range of neurological and biological functions.It has been recognized that the movement can promote plasma galanin concentration and galanin has a protective mechanism in type 2 diabetic patients.Both galanin and insulin can reduce blood glucose level,and diabetes mellitus is the result of the common barriers of galanin and insulin.Therefore,combination of galanin and insulin becomes a focus that whether the combination effects on skeletal muscle glucose transporter protein 4 membrane displacement is better than that of galanin or insulin alone.