冠心病患者红细胞分布宽度与冠状动脉病变程度的相关性分析

目的探讨冠心病患者中红细胞分布宽度(RDW)与冠状动脉病变程度的相关性。方法将102例冠脉造影确诊为冠心病患者,分为稳定性心绞痛组(SAP),不稳定性心绞痛组(UA)和急性心肌梗死组(AMI),据造影结果进行Gensini评分,对不同组别患者RDW水平、血脂水平、高敏C反应蛋白(hs-CRP)、白细胞计数(WBC)、同型半胱氨酸(Hcy)水平进行分析。结果冠心病组患者的血脂水平、Hcy、hs-CRP及WBC的水平均比对照组更高。SAP、UAP、AMI组RDW值均较对照组高(P0.05);AMI组与UAP、SAP组相比RDW值更高,差异显著(P0.01);RDW值随Gensini积分增加依次增大(P0.05),两者呈直线正相关(P0.01);患者中的血脂、hs-CRP、WBC、Hcy水平与RDW均存在正相关。结论红细胞分布宽度水平可作为冠心病患者冠状动脉粥样硬化严重程度的预测指标。

Correlation between red blood cell distribution width and severity of coronary artery lesion in patients with coronary heart disease

Objective To study the association between red blood cell distribution width (RDW) level and severity of coronary vessels of patients with coronary artery disease (CAD). Methods 102 patients with CAD were divided into 3 groups:stable angina pectoris (SAP) group,unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group. Gensini score was evalu-ated according coronary angiography (CAG) result. The RDW levels,lipid Levels,high sensitive C reactive protein (hs-CRP),white blood cell count (WBC),homocysteinemia levels (Hcy) of different groups were measured and studied. Results For CAD patients, the levels of lipid,Hcy,hs-CRP,WBC were higher than those in healthy control. The RDW levels in SAP,UAP and AMI groups were higher than that in healthy control (P<0.05). RDW levels in AMI group were even higher than that in SAP and UAP group, which showed significant difference (P<0.01). The more RDW increased,the higher Gensini score was (P<0.01). And the levels of lipid,hs-CRP,WBC,Hcy in CAD patients’ were positively correlated with RDW level. Conclusion The RDW level can be a good parameter to predict the severity of coronary vessels atherosclerosis.