益生菌预防自发性腹膜炎再发的临床研究

目的探讨益生菌药物对自发性腹膜炎（SBP）再发的预防效果。方法51例肝硬化并SBP治疗后，在综合护肝治疗的基础上随机分为3组：A组18例，除外综合治疗外无其他用药；B组20例，予益生菌口服；C组13例，予喹诺酮类药物口服。观察其自发性腹膜炎再发生率。结果A组与B组比较，SBP再发生率高（x2=3．99，P〈o．05）。A组与B、C组比较，SBP再发生率高，差异有统计学意义（x2=5．26，P〈0．05）。B组与C组比较，x2=0．001，P〉0．05，两治疗组间差异无统计学意义。结论益生菌对预防自发性腹膜炎再发有效。

Clinical study on probiotics in preventing the recurrence of spontaneous bacterial peritonitis

Objective To investigate the prophylactic effect of probiotics to prevent the recurrence of spontaneous bacterial peritonitis(SBP).Method 51 patients with liver cirrhosis complicated with SBP were randomly divided into 3 groups after treated with hepatoprotection: Group A as the control group(n=18);Group B treated with probiotics(n=20) and Group C treated with Quinolones(n=13).Result The recurrence rate of Group B(44.44%) was significantly lower than that of Group A(15%)(χ2=3.99,P<0.05).The recurrence rate of both Group B and C was significantly lower than that of Group A(χ2=5.26,P<0.05).There was no significant difference between Groups B and C(χ2=0.001,P>0.05).ConclusionProbiotics can prevent the recurrence of spontaneous bacterial peritonitis effectively.