| 急性白血病遗传学改变的预后分析及微小残留病检测 |
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| 引用本文： | 刘以俊,;周婧倩,;王慧莹,;金卢阳,;孙婧,;何颖芝,;李玉华.急性白血病遗传学改变的预后分析及微小残留病检测[J].医学综述,2014(15):2694-2696. |
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| 作者姓名： | 刘以俊 ;周婧倩 ;王慧莹 ;金卢阳 ;孙婧 ;何颖芝 ;李玉华 |
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| 作者单位： | [1]南方医科大学第二临床医学院,广州510282; [2]南方医科大学珠江医院血液科,广州510282 |
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| 基金项目： | 广东省暨国家级大学生创新创业训练计划项目（201212121078）;广东省大学生创新实验计划（1212111001）;教育部新世纪优秀人才支持计划（NCET-09-0087）;广东省自然科学基金重点项目（9251051501000007）;广州市科技计划重点项目（12C22121595）;教育部留学回国人员科研启动基金 |
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| 摘 要： | 随着化疗、靶向治疗等技术的进展,白血病的治疗效果日益改善,但复发仍是一大难题。白血病微小残留病(MRD)是指患者达血液学完全缓解后体内仍残留106109/L白血病细胞计数的状态,为白血病复发的主要原因。因此,监测MRD具有重要的临床意义。近年来发现越来越多的异常表达基因有望用于MRD的检测,从而监测复发,提示预后。该文选取WT1(Wilms's tumor-1 gene)、尾型同源盒基因2和表皮生长因子受体通路底物8基因的临床意义予以综述。
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| 关 键 词： | 急性白血病 微小残留病 异常表达基因 预后 复发 |
Prognostic Analysis of the Genetic Changes of Acute Leukemia and Tests for Minimal Residual Disease |
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| Affiliation: | LIU Yi-jun , ZHOU Jing-qian, WANG Hui-ying , JIN Lu-yang , SUN Jing , liE Ying-zhi, LI Yu-hua ( 1. Second Clinical Medical College of Southern Medical University, Guangzhou 510282, China ; 2. Department of Hematoloy , Southern Medical University Zhujiaag Hosipital, Guangzhou 510282, China) |
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| Abstract: | Along with the development of chemotherapy, targeted therapy etc. , the therapeutic effect for leukemia has been improving by day, however, recurrence is still a major problem. 106-109/L leukemic cells residues in the human body after complete hematologic response, which is called minimal residual disease （MRD） and is the major cause of recurrence of leukemia, therefore, the monitor of MRD is of great clinical significance. In recent years, more and more genes are expected to be used in tests for MRD to monitor the recurrence and indicate the prognosis. Here is to make a review of the clinical significance of genes like WT1, PTEN, CDX2 and EpsS. |
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| Keywords: | Acute leukemia Minimal residual disease Abnormally expressed genes Prognosis Recurrence |
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