血清sST2蛋白预测急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗后心力衰竭的临床研究

目的:探究与分析血清可溶性致癌抑制因子-2（sST2）蛋白预测急性ST段抬高型心肌梗死患者经皮冠状动脉介入（PCI）治疗后心力衰竭的价值。方法:回顾性分析，选取2019年6月至2021年1月滨州市中心医院收治急性ST段抬高型心肌梗死患者110例的临床资料，所有患者均接受PCI治疗，对比患者在入院时、术后即刻的血清sST...

Clinical study on serum sST2 protein in predicting heart failure in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention

Objective　To explore and analyze the clinical value of serum soluble suppression of tumorigenicity 2 (sST2) protein in predicting heart failure in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention (PCI) treatment. Methods　The clinical data of 110 patients with acute ST-segment elevation myocardial infarction treated in Binzhou Central Hospital from June 2019 to January 2021 were selected for the retrospective analysis, and all the patients received PCI. The serum sST2 protein levels at the time of admission and immediately after surgery were compared. At the same time all the patients were divided into a heart failure group (29 cases) and a non-heart failure group (81 cases) according to whether the patients developed heart failure within 6 months after PCI, and the serum sST2 protein levels of the two groups were compared. Single factor analysis was used firstly, and then logistic regression analysis was used to analyze the high-risk factors affecting heart failure after PCI. χ² test was used for the count data and t test was used for the measurement data. Results　The serum sST2 protein level in the 110 patients immediately after surgery was significantly higher than that at the time of admission (73.35±20.69) μg/L vs. (51.24±12.58) μg/L], with a statistically significant difference (t=9.577, P<0.001). According to the multivariate logistic analysis, the high-risk factors for heart failure in patients with acute ST-segment elevation myocardial infarction after PCI included older age, multiple site infarction, number of lesions ≥2, left ventricular ejection fraction (LVEF) <50%, time from onset to PCI ≥12 h, serum sST2 protein level immediately after PCI, and slow or no reflow after PCI (all P<0.05). Conclusions　The patients with acute ST-segment elevation myocardial infarction may have elevated serum sST2 protein level immediately after PCI. At the same time, the serum sST2 protein level is higher in patients with postoperative heart failure. Older age, multiple site infarction, number of lesions ≥2, LVEF <50%, time from onset to PCI ≥12 h, serum sST2 protein level immediately after PCI, and slow or no reflow after PCI can all be considered as the high-risk factors affecting heart failure in patients with acute ST segment elevation myocardial infarction after PCI.